Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, 530045, India.
King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.
Curr Med Chem. 2021;28(28):5674-5698. doi: 10.2174/0929867328666201209100659.
The breast tumor microenvironment (TME) promotes drug resistance through an elaborated interaction of TME components mediated by reactive oxygen species (ROS). Although there is massive accumulation of data concerning the targeting of the ROS, little is known about the ROS-responsive nanomedicine for targeting breast TME. This review submits the ROS landscape in breast TME, including ROS biology, ROS mediated carcinogenesis, and reprogramming of stromal and immune cells of TME. We also discussed ROS-based precision strategies for imaging TME, including molecular imaging techniques with advanced probes, multiplexed methods, and multi-omic profiling strategies. ROS-responsive nanomedicine also describes various therapies, such as chemo- dynamic, photodynamic, photothermal, sono-dynamic, immune, and gene therapy for BC. We expound ROS-responsive primary delivery systems for chemotherapeutics, phytochemicals, and immunotherapeutics. This review also presents recent updates on nanotheranostics for simultaneous diagnosis and treatment of BCs. We assume that a review on this advancing field will be beneficial to the development of ROS-based nano-theranostics for BC.
乳腺肿瘤微环境（TME）通过活性氧物质（ROS）介导的 TME 成分的精细相互作用促进耐药性。尽管有大量关于 ROS 靶向治疗的数据积累，但对于针对乳腺 TME 的 ROS 响应性纳米医学知之甚少。本综述介绍了乳腺 TME 中的 ROS 情况，包括 ROS 生物学、ROS 介导的癌变以及 TME 中基质和免疫细胞的重编程。我们还讨论了基于 ROS 的 TME 成像的精准策略，包括具有先进探针的分子成像技术、多重方法和多组学分析策略。ROS 响应性纳米医学还描述了各种治疗方法，如化疗动力学、光动力、光热、声动力、免疫和基因治疗 BC。我们阐述了针对化疗药物、植物化学物质和免疫治疗药物的 ROS 响应性初级递送系统。本综述还介绍了用于 BC 同时诊断和治疗的纳米治疗学的最新进展。我们假设对这一不断发展的领域的综述将有助于开发基于 ROS 的 BC 纳米治疗学。
