补充姜黄素对认知功能的影响：一项更新的系统评价和荟萃分析。

The effect of curcumin supplementation on cognitive function: an updated systematic review and meta-analysis.

作者信息

Wang Wenlong, Zhao Rui, Liu Bingzheng, Li Kelei

机构信息

Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Institute of Nutrition and Health, Qingdao University, Qingdao, China.

出版信息

Front Nutr. 2025 Apr 16;12:1549509. doi: 10.3389/fnut.2025.1549509. eCollection 2025.

DOI:10.3389/fnut.2025.1549509

PMID:40308636

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040662/

Abstract

BACKGROUND

Previous randomized controlled trials (RCTs) did not draw a consistent conclusion about the effect of curcumin on cognitive function.

METHODS

We searched Web of Science, PubMed, Cochrane Library and Embase, and 9 RCTs (including 12 independent comparisons) with 501 subjects were included in the present meta-analysis.

RESULTS

Compared with placebo, supplementation of curcumin significantly improved global cognitive function (SMD, 0.82; 95% CI, 0.19 to 1.45; = 0.010). A curvilinear dose-response effect was observed, and the optimal dose is 0.8 g/day. Subgroup analysis indicated that the beneficial effect of curcumin on cognition was significant only if duration ≥24 weeks (SMD, 1.15; 95% CI, 0.13 to 2.18; = 0.027), age of participants ≥60 years (SMD, 1.12; 95% CI, 0.03 to 2.21; = 0.044), or participants from Asian countries (SMD, 0.96; 95% CI, 0.08 to 1.83; = 0.032). Otherwise, this effect became non-significant ( > 0.05). Sensitivity analysis by excluding each study one by one or excluding all studies with high risk of bias did not obviously influence the final results. No significant publication bias was observed (P for Begg's Test and Egger's test = 0.150 and 0.493, respectively).

CONCLUSION

Supplementation of curcumin can effectively improve global cognitive function, and the optimal dose and duration is 0.8 g/day and ≥24 weeks. The beneficial effect of curcumin on cognition is more potent in older and Asian participants than younger and Western ones.

摘要

背景

先前的随机对照试验（RCT）对于姜黄素对认知功能的影响并未得出一致结论。

方法

我们检索了科学网、PubMed、考克兰图书馆和Embase，本荟萃分析纳入了9项随机对照试验（包括12项独立比较），共501名受试者。

结果

与安慰剂相比，补充姜黄素显著改善了整体认知功能（标准化均数差，0.82；95%置信区间，0.19至1.45；P = 0.010）。观察到一种曲线剂量反应效应，最佳剂量为0.8克/天。亚组分析表明，仅当持续时间≥24周（标准化均数差，1.15；95%置信区间，0.13至2.18；P = 0.027）、参与者年龄≥60岁（标准化均数差，1.12；95%置信区间，0.03至2.21；P = 0.044）或参与者来自亚洲国家（标准化均数差，0.96；95%置信区间，0.08至1.83；P = 0.032）时，姜黄素对认知的有益作用才显著。否则，这种效应变得不显著（P>0.05）。通过逐一排除每项研究或排除所有存在高偏倚风险的研究进行的敏感性分析并未明显影响最终结果。未观察到显著的发表偏倚（Begg检验和Egger检验的P值分别为0.150和0.493）。