Kim S H, Handa H, Ishikawa M, Hirai O, Yoshida S, Imadaka K
J Cereb Blood Flow Metab. 1985 Sep;5(3):432-8. doi: 10.1038/jcbfm.1985.58.
Regional changes of brain tissue pH and its correlation to energy metabolism were studied in various degrees of incomplete ischemia for 5 and 60 min in the unilateral common carotid occlusion of normally fed mongolian gerbils. The degree of ischemia was evaluated by the severity of neurological deficits following 60 min of occlusion, and animals were divided into three groups: symptomatic, borderline, and asymptomatic. Changes of NADH and ATP distribution corresponded well to the degree of ischemia. On the other hand, acidosis developed more clearly and extended in wider areas than the changes of NADH and ATP distribution. These changes were already seen at 5 min of occlusion. From the results of this experiment, it was suspected that acidosis in mild incomplete ischemia was due to stimulated anaerobic glycolysis that might supplement NADH oxidation and ATP yields. Further, acidosis without energy failure was considered not to be detrimental to neuronal cells.
在正常喂养的蒙古沙鼠单侧颈总动脉闭塞导致不同程度不完全缺血5分钟和60分钟的情况下，研究了脑组织pH值的区域变化及其与能量代谢的相关性。通过闭塞60分钟后神经功能缺损的严重程度评估缺血程度，动物被分为三组：有症状组、临界组和无症状组。NADH和ATP分布的变化与缺血程度密切相关。另一方面，酸中毒比NADH和ATP分布的变化更明显，且在更广泛的区域扩展。这些变化在闭塞5分钟时就已出现。从该实验结果推测，轻度不完全缺血时的酸中毒是由于无氧糖酵解受刺激，这可能补充了NADH氧化和ATP生成。此外，无能量衰竭的酸中毒被认为对神经元细胞无害。
