Borrás-Sansaloni Carmen, Ricco-Pérez Marina, Mayol Antoni, Navarro-Guzmán Capilla, García-Montes José Manuel, Lopez-Navarro Emilio
Department of Psychology, University of Balearic Islands, Palma 07122, Balearic Islands, Spain.
Beatles Research Group, University of Balearic Islands, Palma 07122, Balearic Islands, Spain.
World J Psychiatry. 2025 Apr 19;15(4):103362. doi: 10.5498/wjp.v15.i4.103362.
Psychotic disorders are characterized by both positive symptoms (hallucinations, delusions) and negative symptoms (emotional blunting, anhedonia) that impair daily functioning. While antipsychotic drugs and psychological interventions are effective when addressing positive symptoms, treatment of negative symptoms remains an ongoing challenge. Mindfulness-based interventions (MBIs) have been shown to reduce negative psychotic symptoms. However, as negative psychotic symptoms are assessed as a sole entity rather than a sum of manifestations, the effect of MBIs remains unclear.
To examine the effects of MBI in addition to integrated rehabilitation treatment (IRT) for people experiencing psychosis on each of the negative psychotic symptoms.
A randomized controlled clinical trial with preintervention and postintervention measures was designed. The main outcome variable was negative psychotic symptoms assessed through the seven subscales of the Spanish version of the positive and negative syndrome scale. Data were analyzed using a repeated measures analysis of variance and reliable change index calculation.
There were no statistical differences between groups at the preintervention assessment. Statistically significant differences were found after MBI for the time in emotional withdrawal ( = 37.75, < 0.001, = 0.437) and social withdrawal ( = 37.75, < 0.001, = 0.437).
MBI added to IRT reduced the lack of interest and involvement with affective commitment to daily life activities, and interest and engagement in social activities increased. These negative psychotic symptoms were not improved by IRT alone.
精神障碍的特征是存在损害日常功能的阳性症状(幻觉、妄想)和阴性症状(情感迟钝、快感缺乏)。虽然抗精神病药物和心理干预在治疗阳性症状时有效,但阴性症状的治疗仍然是一个持续存在的挑战。基于正念的干预措施(MBIs)已被证明可减轻阴性精神病症状。然而,由于阴性精神病症状是作为一个单独的实体而非一系列表现进行评估的,MBIs的效果仍不明确。
研究在综合康复治疗(IRT)基础上增加MBI对精神病患者各阴性精神病症状的影响。
设计一项采用干预前和干预后测量的随机对照临床试验。主要结局变量是通过阳性和阴性症状量表西班牙语版的七个分量表评估的阴性精神病症状。使用重复测量方差分析和可靠变化指数计算对数据进行分析。
干预前评估时两组之间无统计学差异。在MBI治疗后,发现情感退缩(F = 37.75,p < 0.001,η² = 0.437)和社交退缩(F = 37.75,p < 0.001,η² = 0.437)方面存在统计学显著差异。
在IRT基础上增加MBI可减少对日常生活活动缺乏兴趣和情感投入,并且对社交活动的兴趣和参与度增加。仅IRT并不能改善这些阴性精神病症状。