This paper deals with quality of life (QoL), mental well-being (WB), anxiousness, and stress vulnerability in women with tetany syndrome (TS) in comparison with the population without the syndrome. The aim is to investigate the individual or combined effects of anxiousness, stress vulnerability, and tetany syndrome diagnosis on quality of life and well-being in women. : The research sample was composed of 144 female (in terms of sex) respondents with a diagnosis of tetany syndrome and 123 females without the syndrome (comparative group). The questionnaire battery was used for data collection (WHOQoL-BREF, Warwick-Edinburgh mental well-being scale, STAI (X-2), and Stress Vulnerability Scale). In processing, comparisons, correlations, and MANCOVA analyses were used. : The group with tetany syndrome showed significantly lower levels of quality of life (all domains) and well-being and significantly higher anxiousness compared to the group without the syndrome. In vulnerability to stress, a significant difference between groups was not shown. Multivariate testing showed a small interaction effect of tetany syndrome, anxiousness, and stress vulnerability on well-being and quality of life, while anxiousness still had the largest independent effect. : Lifestyle aspects seem to be a possible intervening factor that, in interaction with anxiety, contributes to a worse quality of life and well-being in individuals with tetany syndrome. The results contribute to the perception of psychological intervention, in terms of stress management and support for a healthy lifestyle, as important in addition to mineral supplementation or medication treatment.