Veltri E P, Reid P R
J Am Coll Cardiol. 1985 Oct;6(4):802-5. doi: 10.1016/s0735-1097(85)80486-1.
Amiodarone is an investigational antiarrhythmic agent known to cause pulmonary toxicity. This report describes two patients with previous amiodarone pulmonary toxicity and complete resolution who at rechallenge 5 to 6 months later developed within 2 weeks of therapy a significant reduction in lung diffusion capacity before overt clinical toxicity occurred. This suggests that toxicity may present early with reduction in diffusion capacity and that such changes may warrant the need to alter treatment.
胺碘酮是一种已知会导致肺毒性的研究性抗心律失常药物。本报告描述了两名曾患胺碘酮所致肺毒性且已完全康复的患者，他们在5至6个月后再次接受该药治疗时，在治疗的2周内，在明显的临床毒性出现之前，肺弥散能力就出现了显著下降。这表明毒性可能早期表现为弥散能力降低，而这种变化可能需要改变治疗方案。
