一例胺碘酮相关的肺毒性病例。

A case of amiodarone-associated pulmonary toxicity.

作者信息

Kwon K H, Jeong S W, Uh S, Kim Y H, Jin S Y, Park J S, Kang C H, Park C S

机构信息

Department of Internal Medicine, Anatomical Pathology, College of Medicine, Soon Chun Hy ang University, Seoul, Korea.

出版信息

Korean J Intern Med. 1995 Jul;10(2):155-9. doi: 10.3904/kjim.1995.10.2.155.

DOI:10.3904/kjim.1995.10.2.155

PMID:7495776

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4532041/

Abstract

Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia. There are numerous side effects associated with amiodarone therapy, including corneal microdeposits. Skin reactions and others. Pulmonary toxicity, however, represents the most serious adverse reaction limiting the clinical effecacy of this antidysrhythmic drug. Recently, we experienced a case of amiodarone-induced pulmonary toxicity confirmed by open lung biopsy with light-and electron-microscopy. So, we report a case of amiodarone-induced pulmonary toxicity with a literature review.

摘要

胺碘酮是一种碘化苯并呋喃衍生物，是治疗某些危及生命的难治性心律失常的一种全新且极为有效的疗法。胺碘酮治疗存在众多副作用，包括角膜微沉积物、皮肤反应等。然而，肺毒性是限制这种抗心律失常药物临床疗效的最严重不良反应。最近，我们遇到一例经开放性肺活检及光镜和电镜检查确诊的胺碘酮所致肺毒性病例。因此，我们报告一例胺碘酮所致肺毒性病例并进行文献复习。