• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种利用UiO-66金属有机框架-氧化石墨烯纳米复合材料修饰的碳糊电极在尿酸存在下测量多巴胺的新方法。

A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite.

作者信息

Gatea Azhar Hameed, Ajel Aseer Shakir, Mhaibes Raed Muslim

机构信息

Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar 64001, Iraq.

Department of Biochemistry, College of Medicine, Misan University, Misan, Iraq.

出版信息

ADMET DMPK. 2025 Feb 4;13(2):2593. doi: 10.5599/admet.2593. eCollection 2025.

DOI:10.5599/admet.2593
PMID:40314004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12043105/
Abstract

BACKGROUND AND PURPOSE

Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess dopamine and uric acid levels.

EXPERIMENTAL APPROACH

Using electrochemical techniques, a new Universitet i Oslo MOF (UiO-66)-graphene oxide nanocomposite-modified carbon paste electrode was created to investigate the electrooxidation of uric acid and dopamine as well as their combinations. At the redesigned electrode, uric acid and dopamine were detected concurrently in a very sensitive way using differential pulse voltammetry (DPV).

KEY RESULTS

Dopamine DPV peak currents increase in a linear fashion at doses between 0.05 and 600.0 μM.

CONCLUSION

Uric acid and dopamine levels in urine and dopamine injection samples may be determined with the help of the proposed sensor, which is reasonably priced and performs well.

摘要

背景与目的

多巴胺对心血管、内分泌、肾脏及中枢神经系统均有影响。电化学技术作为评估多巴胺和尿酸水平的一种方法，在研究人员中越来越受欢迎。

实验方法

采用电化学技术，制备了一种新型的奥斯陆大学金属有机框架材料（UiO - 66）-氧化石墨烯纳米复合修饰碳糊电极，用于研究尿酸和多巴胺及其混合物的电氧化过程。在重新设计的电极上，采用差分脉冲伏安法（DPV）以非常灵敏的方式同时检测尿酸和多巴胺。

关键结果

多巴胺DPV峰电流在0.05至600.0 μM剂量范围内呈线性增加。

结论

所提出的传感器价格合理且性能良好，有助于测定尿液和多巴胺注射样品中的尿酸和多巴胺水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/542184ed5515/ADMET-13-2593-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/e92385dc1b9e/ADMET-13-2593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/b61af87f1c4e/ADMET-13-2593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/f01194af9972/ADMET-13-2593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/da3a98fdda41/ADMET-13-2593-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/69c4b46ee909/ADMET-13-2593-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/29330c30c596/ADMET-13-2593-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/542184ed5515/ADMET-13-2593-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/e92385dc1b9e/ADMET-13-2593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/b61af87f1c4e/ADMET-13-2593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/f01194af9972/ADMET-13-2593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/da3a98fdda41/ADMET-13-2593-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/69c4b46ee909/ADMET-13-2593-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/29330c30c596/ADMET-13-2593-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7384/12043105/542184ed5515/ADMET-13-2593-g007.jpg

相似文献

1
A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite.一种利用UiO-66金属有机框架-氧化石墨烯纳米复合材料修饰的碳糊电极在尿酸存在下测量多巴胺的新方法。
ADMET DMPK. 2025 Feb 4;13(2):2593. doi: 10.5599/admet.2593. eCollection 2025.
2
Dopamine and uric acid electrochemical sensor based on a glassy carbon electrode modified with cubic Pd and reduced graphene oxide nanocomposite.基于立方相钯和还原氧化石墨烯纳米复合材料修饰玻碳电极的多巴胺和尿酸电化学传感器。
J Colloid Interface Sci. 2017 Jul 1;497:172-180. doi: 10.1016/j.jcis.2017.03.011. Epub 2017 Mar 2.
3
Simultaneous Determination of Dopamine and Uric Acid in Real Samples Using a Voltammetric Nanosensor Based on Co-MOF, Graphene Oxide, and 1-Methyl-3-butylimidazolium Bromide.基于钴基金属有机框架、氧化石墨烯和1-甲基-3-丁基溴化咪唑鎓的伏安纳米传感器同时测定实际样品中的多巴胺和尿酸
Micromachines (Basel). 2022 Oct 27;13(11):1834. doi: 10.3390/mi13111834.
4
A facile electrochemical sensor based on a composite of electrochemically reduced graphene oxide and a PEDOT:PSS modified glassy carbon electrode for uric acid detection.基于电化学还原氧化石墨烯和聚（3,4-乙烯二氧噻吩）：聚苯乙烯磺酸盐修饰玻碳电极的尿酸电化学传感器的制备。
Anal Sci. 2022 Jan;38(1):157-166. doi: 10.2116/analsci.21P214. Epub 2022 Feb 28.
5
Electrochemical determination of dopamine and uric acid using a glassy carbon electrode modified with a composite consisting of a Co(II)-based metalorganic framework (ZIF-67) and graphene oxide.使用玻碳电极修饰 Co(II)基金属有机骨架（ZIF-67）和氧化石墨烯复合材料测定多巴胺和尿酸的电化学方法。
Mikrochim Acta. 2018 Oct 1;185(10):486. doi: 10.1007/s00604-018-3025-x.
6
Construction of cationic polyfluorinated azobenzene/reduced graphene oxide for simultaneous determination of dopamine, uric acid and ascorbic acid.构建阳离子型全氟偶氮苯/还原氧化石墨烯用于同时测定多巴胺、尿酸和抗坏血酸。
Talanta. 2022 Jan 15;237:122986. doi: 10.1016/j.talanta.2021.122986. Epub 2021 Oct 20.
7
High-index {hk0} facets platinum concave nanocubes loaded on multiwall carbon nanotubes and graphene oxide nanocomposite for highly sensitive simultaneous detection of dopamine and uric acid.高折射率{hk0}面铂金凹纳米立方体负载在多壁碳纳米管和氧化石墨烯纳米复合材料上，用于同时高灵敏检测多巴胺和尿酸。
Talanta. 2020 Jan 15;207:120296. doi: 10.1016/j.talanta.2019.120296. Epub 2019 Aug 25.
8
Phytic acid/graphene oxide nanocomposites modified electrode for electrochemical sensing of dopamine.植酸/氧化石墨烯纳米复合材料修饰电极电化学传感多巴胺。
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:1086-1089. doi: 10.1016/j.msec.2016.11.023. Epub 2016 Nov 9.
9
Electrochemical Co-Reduction Synthesis of AuPt Bimetallic Nanoparticles-Graphene Nanocomposites for Selective Detection of Dopamine in the Presence of Ascorbic Acid and Uric Acid.用于在抗坏血酸和尿酸存在下选择性检测多巴胺的金铂双金属纳米颗粒-石墨烯纳米复合材料的电化学共还原合成
Sensors (Basel). 2015 Jul 9;15(7):16614-31. doi: 10.3390/s150716614.
10
Iron nanoparticles decorated multi-wall carbon nanotubes modified carbon paste electrode as an electrochemical sensor for the simultaneous determination of uric acid in the presence of ascorbic acid, dopamine and L-tyrosine.铁纳米粒子修饰的多壁碳纳米管修饰碳糊电极作为电化学传感器，用于在抗坏血酸、多巴胺和 L-酪氨酸存在下同时测定尿酸。
Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:328-37. doi: 10.1016/j.msec.2015.08.003. Epub 2015 Aug 8.

引用本文的文献

1
Facile synthesis and characterization of nanorods Pb-MOF for toxic rodenticide detection.用于检测有毒灭鼠剂的纳米棒状铅基金属有机框架材料的简易合成与表征
BMC Chem. 2025 Jul 22;19(1):219. doi: 10.1186/s13065-025-01579-y.

本文引用的文献

1
Wireless single-electrode electrochemiluminescence device based on wireless reverse charging or on-the-go USB transmission for multiplex analysis.
Chem Commun (Camb). 2024 Nov 14;60(92):13546-13549. doi: 10.1039/d4cc04873c.
2
Highly sensitive determination of trace arsenic(III) onto carbon paste electrode modified with graphitic carbon nitride decorated Fe-MOF.高灵敏度测定痕量砷(III)于石墨相氮化碳修饰的 Fe-MOF 修饰的碳糊电极上。
Food Chem. 2024 Nov 15;458:140296. doi: 10.1016/j.foodchem.2024.140296. Epub 2024 Jul 1.
3
Voltammetric determination of organic UV filters by carbon paste electrodes modified with pyridinium-based ionic liquids.基于吡啶鎓离子液体修饰的碳糊电极伏安法测定有机紫外线滤光剂
Talanta. 2024 Jan 1;266(Pt 2):125103. doi: 10.1016/j.talanta.2023.125103. Epub 2023 Aug 22.
4
Determination of D&C Red 33 and Patent Blue V Azo dyes using an impressive electrochemical sensor based on carbon paste electrode modified with ZIF-8/g-CN/Co and ionic liquid in mouthwash and toothpaste as real samples.使用基于ZIF-8/g-CN/Co修饰的碳糊电极和离子液体的令人印象深刻的电化学传感器测定漱口液和牙膏等实际样品中的D&C红33和专利蓝V偶氮染料。
Food Chem Toxicol. 2022 Apr;162:112907. doi: 10.1016/j.fct.2022.112907. Epub 2022 Mar 7.
5
A Facile Method for Preparing UiO-66 Encapsulated Ru Catalyst and its Application in Plasma-Assisted CO Methanation.一种制备UiO-66封装钌催化剂的简便方法及其在等离子体辅助CO甲烷化中的应用。
Nanomaterials (Basel). 2019 Oct 10;9(10):1432. doi: 10.3390/nano9101432.
6
Nano metal-organic framework (NMOF)-based strategies for multiplexed microRNA detection in solution and living cancer cells.基于纳米金属-有机骨架（NMOF）的策略，用于溶液和活癌细胞中多重 microRNA 的检测。
Nanoscale. 2015 Feb 7;7(5):1753-9. doi: 10.1039/c4nr05447d.
7
Near-infrared electrogenerated chemiluminescence of ultrasmall Ag2Se quantum dots for the detection of dopamine.用于多巴胺检测的超小 Ag2Se 量子点的近红外电致化学发光。
Anal Chem. 2012 Nov 6;84(21):8932-5. doi: 10.1021/ac301835f. Epub 2012 Oct 11.
8
Arvid Carlsson, and the story of dopamine.阿尔维德·卡尔森与多巴胺的故事。
Indian J Psychiatry. 2010 Jan;52(1):87-8. doi: 10.4103/0019-5545.58907.