一种利用UiO-66金属有机框架-氧化石墨烯纳米复合材料修饰的碳糊电极在尿酸存在下测量多巴胺的新方法。

A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite.

作者信息

Gatea Azhar Hameed, Ajel Aseer Shakir, Mhaibes Raed Muslim

机构信息

Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar 64001, Iraq.

Department of Biochemistry, College of Medicine, Misan University, Misan, Iraq.

出版信息

ADMET DMPK. 2025 Feb 4;13(2):2593. doi: 10.5599/admet.2593. eCollection 2025.

BACKGROUND AND PURPOSE

Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess dopamine and uric acid levels.

EXPERIMENTAL APPROACH

Using electrochemical techniques, a new Universitet i Oslo MOF (UiO-66)-graphene oxide nanocomposite-modified carbon paste electrode was created to investigate the electrooxidation of uric acid and dopamine as well as their combinations. At the redesigned electrode, uric acid and dopamine were detected concurrently in a very sensitive way using differential pulse voltammetry (DPV).

KEY RESULTS

Dopamine DPV peak currents increase in a linear fashion at doses between 0.05 and 600.0 μM.

CONCLUSION

Uric acid and dopamine levels in urine and dopamine injection samples may be determined with the help of the proposed sensor, which is reasonably priced and performs well.