Rapani Antonio, Tonegato Leonardo, Savadori Paolo, Martini Rebecca, Pasquali Riccardo, Zotti Matteo, Nicolin Vanessa, Berton Federico, Stacchi Claudio
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Clin Implant Dent Relat Res. 2025 Jun;27(3):e70048. doi: 10.1111/cid.70048.
This study aimed to evaluate the efficacy of Biologically oriented Alveolar Ridge Preservation (BARP) in minimizing post-extraction ridge modifications compared with unassisted socket healing.
A prospective controlled observational study was conducted involving 30 patients requiring single-rooted upper premolar extractions. Patients were divided into two groups: the test (15 patients), which underwent a ridge preservation procedure combining absorbable collagen sponge in the middle and apical third of the socket and collagenated xenogeneic bone substitute in the most coronal part (BARP), and the control (15 patients), which healed spontaneously. Soft tissue contour changes after 6 months were analyzed using digital impressions. Moreover, histomorphometric analysis of the regenerated tissue was performed in the test group.
BARP significantly reduced post-extractive mucosal ridge modifications compared to the control group. Mean vertical shrinkage at the mid-buccal part of the edentulous site was 1.61 ± 0.61 mm (BARP) vs. 2.51 ± 0.64 mm (control; t-test, df = 28, p < 0.001), and mean horizontal reduction was 3.37 ± 0.63 mm (BARP) vs. 4.34 ± 0.48 mm (control; t-test, df = 28, p < 0.001). Histomorphometric analysis of the regenerated tissue showed 39.7% ± 9.1% newly formed bone with minimal residual graft material (5.0% ± 5.4%).
BARP technique effectively minimizes post-extractive soft tissue contour modifications and supports natural bone regeneration, resulting in adequate bone dimensions for implant rehabilitation.
本研究旨在评估生物导向性牙槽嵴保存（BARP）与无辅助牙槽窝愈合相比，在最小化拔牙后牙槽嵴改变方面的疗效。
进行了一项前瞻性对照观察研究，纳入30例需要拔除单根上颌前磨牙的患者。患者分为两组：试验组（15例患者），接受牙槽嵴保存程序，在牙槽窝的中部和根尖三分之一处联合使用可吸收胶原海绵，并在最冠方部分使用胶原化异种骨替代物（BARP）；对照组（15例患者），自然愈合。6个月后使用数字印模分析软组织轮廓变化。此外，对试验组再生组织进行组织形态计量分析。
与对照组相比，BARP显著减少了拔牙后黏膜牙槽嵴的改变。无牙区颊侧中部的平均垂直收缩为1.61±0.61毫米（BARP），而对照组为2.51±0.64毫米（t检验，自由度=28，p<0.001）；平均水平减少为3.37±0.63毫米（BARP），而对照组为4.34±0.48毫米（t检验，自由度=28，p<0.001）。再生组织的组织形态计量分析显示，新形成骨为39.7%±9.1%，残留移植材料极少（5.0%±5.4%）。
BARP技术有效地最小化了拔牙后软组织轮廓的改变，并支持天然骨再生，从而为种植修复提供足够的骨尺寸。
