Minetti Elio, Palermo Andrea, Savadori Paolo, Patano Assunta, Inchingolo Alessio Danilo, Rapone Biagio, Malcangi Giuseppina, Inchingolo Francesco, Dipalma Gianna, Tartaglia Francesco Carlo, Inchingolo Angelo Michele
Department of Biomedical, Surgical, and Dental Science, University of Milan, 20122 Milan, Italy.
College of Medicine and Dentistry, Birmingham B4 6BN, UK.
Materials (Basel). 2023 Jul 11;16(14):4945. doi: 10.3390/ma16144945.
The use of human dentin matrix could serve as an alternative to autologous, allogenic, and xenogeneic bone grafts due to its osteoinductive characteristics. The limitations of its use is tooth availability and that it is often necessary to mix it with a biomaterial.
The aim of this study was to analyze a mix of two different graft materials with different reabsorption ranges when the dentin graft material was not sufficient for full socket preservation.
Seven socket preservation surgeries were carried out employing a mixed graft material containing 50% dentin and 50% xenograft. After four months of recovery, the implants were positioned. At the time of the prosthesis placement and implant surgery, bone samples were collected.
The histologic analysis revealed no inflammatory or infective reaction against the seven biopsies. The histomorphometric graft analysis revealed an amount of New Bone of 29.03 ± 6.57% after 4 months and 34.11 ± 5.02% after 8 months.
The two graft materials had a different volume reabsorption rate: 71% after 4 months and 90% after 8 months for dentin, and 6% after 4 months and 26% after 8 months for the xenograft. The space created by the dentin reabsorption increased the quantity of new bone.
由于具有骨诱导特性，人牙本质基质的使用可作为自体、异体和异种骨移植的替代方法。其使用的局限性在于牙齿的可获得性，并且通常需要将其与生物材料混合。
本研究的目的是分析当牙本质移植材料不足以完全保存牙槽窝时，两种具有不同吸收范围的不同移植材料的混合物。
采用含50%牙本质和50%异种移植物的混合移植材料进行了7例牙槽窝保存手术。恢复四个月后植入种植体。在安装假体和进行种植手术时，采集骨样本。
组织学分析显示，对7份活检样本未发现炎症或感染反应。组织形态计量学移植分析显示，4个月后新骨量为29.03±6.57%，8个月后为34.11±5.02%。
两种移植材料具有不同的体积吸收率：牙本质4个月后为71%，8个月后为90%；异种移植物4个月后为6%，8个月后为26%。牙本质吸收产生的空间增加了新骨的数量。
