Baker Jacob S, Qu Evan, Mancuso Christopher P, Tripp A Delphine, Conwill Arolyn, Lieberman Tami D
Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Cell Host Microbe. 2025 May 14;33(5):643-656.e7. doi: 10.1016/j.chom.2025.04.010. Epub 2025 May 1.
Adult human facial skin microbiomes are remarkably similar at the species level, dominated by Cutibacterium acnes and Staphylococcus epidermidis, yet each person harbors a unique community of strains. Understanding how person-specific communities assemble is critical for designing microbiome-based therapies. Here, using 4,055 isolate genomes and 356 metagenomes, we reconstruct on-person evolutionary history to reveal on- and between-person strain dynamics. We find that multiple cells are typically involved in transmission, indicating ample opportunity for migration. Despite this accessibility, family members share only some of their strains. S. epidermidis communities are dynamic, with each strain persisting for an average of only 2 years. C. acnes strains are more stable and have a higher colonization rate during the transition to an adult facial skin microbiome, suggesting this window could facilitate engraftment of therapeutic strains. These previously undetectable dynamics may influence the design of microbiome therapeutics and motivate the study of their effects on hosts.
成年人类面部皮肤微生物群落在物种水平上非常相似，以痤疮丙酸杆菌和表皮葡萄球菌为主导，但每个人都拥有独特的菌株群落。了解特定个体的群落如何组装对于设计基于微生物群的疗法至关重要。在这里，我们使用4055个分离基因组和356个宏基因组，重建个体上的进化历史，以揭示个体内和个体间的菌株动态。我们发现，传播通常涉及多个细胞，这表明有充足的迁移机会。尽管有这种可及性，但家庭成员只共享部分菌株。表皮葡萄球菌群落是动态的，每个菌株平均仅持续2年。痤疮丙酸杆菌菌株更稳定，在向成年面部皮肤微生物群转变期间定植率更高，这表明这个窗口期可能有助于治疗菌株的植入。这些以前无法检测到的动态可能会影响微生物群疗法的设计，并激发对其对宿主影响的研究。
