Beiersdorf AG, Research & Development, Front End Innovation, 20245, Hamburg, Germany.
Department of Microbiology and Biotechnology, University of Hamburg, 22609, Hamburg, Germany.
Commun Biol. 2022 Sep 7;5(1):923. doi: 10.1038/s42003-022-03897-6.
Human skin is populated by trillions of microbes collectively called the skin microbiome. Staphylococcus epidermidis and Cutibacterium acnes are among the most abundant members of this ecosystem, with described roles in skin health and disease. However, knowledge regarding the health beneficial effects of these ubiquitous skin residents is still limited. Here, we profiled the staphylococcal and C. acnes landscape across four different skin sites of 30 individuals (120 skin samples) using amplicon-based next-generation sequencing. Relative abundance profiles obtained indicated the existence of phylotype-specific co-existence and exclusion scenarios. Co-culture experiments with 557 staphylococcal strains identified 30 strains exhibiting anti-C. acnes activities. Notably, staphylococcal strains were found to selectively exclude acne-associated C. acnes and co-exist with healthy skin-associated phylotypes, through regulation of the antimicrobial activity. Overall, these findings highlight the importance of skin-resident staphylococci and suggest that selective microbial interference is a contributor to healthy skin homeostasis.
人类皮肤中栖息着数以万亿计的微生物，这些微生物统称为皮肤微生物组。表皮葡萄球菌和痤疮丙酸杆菌是该生态系统中最丰富的成员之一，它们在皮肤健康和疾病中发挥着作用。然而，人们对于这些普遍存在的皮肤居民对健康有益的影响的了解仍然有限。在这里，我们使用基于扩增子的下一代测序技术，对 30 个人的四个不同皮肤部位（120 个皮肤样本）的葡萄球菌属和痤疮丙酸杆菌属进行了分析。获得的相对丰度图谱表明存在特定于种系型的共存和排斥情景。对 557 株葡萄球菌的共培养实验鉴定出 30 株具有抗痤疮丙酸杆菌活性的菌株。值得注意的是，通过调节抗菌活性，发现葡萄球菌菌株能够选择性地排除与痤疮相关的痤疮丙酸杆菌，并与健康皮肤相关的种系型共存。总的来说，这些发现强调了皮肤常驻葡萄球菌的重要性，并表明选择性的微生物干扰是维持健康皮肤稳态的一个因素。
