Nilsson G E, Tottmar O
J Neurochem. 1985 Sep;45(3):744-51. doi: 10.1111/j.1471-4159.1985.tb04055.x.
When indole-3-acetaldehyde was incubated with rat brain tissue, an aldehyde dehydrogenase-independent irreversible disappearance of the aldehyde was found. This was accompanied by an increase in absorbance at 240-400 nm, with a peak at 310 nm. The results suggested that this change in absorbance was caused by a membrane-bound nonenzymatic reaction between indole-3-acetaldehyde and phospholipids. A similar reaction occurred between indole-3-acetaldehyde and pure preparations of phosphatidylethanolamine and phosphatidylserine, but not phosphatidylcholine. Indole-3-acetaldehyde levels also decreased slightly when incubated with albumin but absorbance at 310 nm was unaltered. It is suggested that nonenzymatic reactions between indole-3-acetaldehyde (or other biogenic aldehydes) and membrane components might occur in vivo, and could be involved in the effects of drugs such as ethanol and barbiturates.
当吲哚 - 3 - 乙醛与大鼠脑组织一起孵育时，发现该醛出现了不依赖醛脱氢酶的不可逆消失。这伴随着在240 - 400nm处吸光度的增加，在310nm处有一个峰值。结果表明，这种吸光度变化是由吲哚 - 3 - 乙醛与磷脂之间的膜结合非酶反应引起的。吲哚 - 3 - 乙醛与磷脂酰乙醇胺和磷脂酰丝氨酸的纯制剂之间也发生了类似反应，但与磷脂酰胆碱没有这种反应。当与白蛋白一起孵育时，吲哚 - 3 - 乙醛水平也略有下降，但310nm处的吸光度未改变。有人提出，吲哚 - 3 - 乙醛（或其他生物源性醛）与膜成分之间的非酶反应可能在体内发生，并可能与乙醇和巴比妥类药物等药物的作用有关。
