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原发性甲状腺功能减退症患儿注射促甲状腺激素释放激素后血浆生长激素水平的升高。

Increase in plasma growth hormone levels following thyrotropin-releasing hormone injection in children with primary hypothyroidism.

作者信息

Collu R, Leboeuf G, Letarte J, Ducharme J R

出版信息

J Clin Endocrinol Metab. 1977 Apr;44(4):743-7. doi: 10.1210/jcem-44-4-743.

DOI:10.1210/jcem-44-4-743
PMID:403195
Abstract

Thyrotropin-releasing hormone (TRH) induced a significant increase in plasma growth hormone (GH) levels in 4 of 8 children with primary hypothyroidism, while a slight decrease was observed in 8 control children. Base-line plasma prolactin (PRL) levels and peak responses to TRH were higher in hypothyroid children than in controls. These data may indicate the existence of dysfunction of central nervous system mechanisms of control of GH and PRL secretion in subjects with primary hypothyroidism.

摘要

促甲状腺激素释放激素（TRH）使8例原发性甲状腺功能减退患儿中的4例血浆生长激素（GH）水平显著升高，而8例对照儿童中观察到GH水平略有下降。甲状腺功能减退儿童的基础血浆催乳素（PRL）水平及对TRH的峰值反应高于对照组。这些数据可能表明原发性甲状腺功能减退患者存在控制GH和PRL分泌的中枢神经系统机制功能障碍。

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