Braun O H, Sandkühler H
J Pediatr Gastroenterol Nutr. 1985 Aug;4(4):583-6. doi: 10.1097/00005176-198508000-00015.
Lysozyme concentrations and bacterial colony counts were determined in 399 human milk samples obtained from 42 mothers (18 mothers of term infants, 24 mothers of preterm or small-for-date neonates). The average lysozyme concentration was 21.39 +/- 13.19 mg/L. Lysozyme concentrations were significantly greater in preterm (24.99 +/- 15.05 mg/L) than in term milk (14.89 +/- 9.83 mg/L) (p less than 0.05). Bacterial colony counts did not decline with increasing lysozyme concentration, i.e., no correlation between lysozyme concentration and bacterial count was found. Despite this lack of correlation, a significant correlation between lysozyme concentration and rate of weight gain was observed: the higher the lysozyme concentration, the better the weight gain. The mechanism of this observation remains to be elucidated; a trophic effect of lysozyme is suggested as a possible mechanism.
对从42名母亲（18名足月儿母亲，24名早产儿或小于胎龄儿母亲）采集的399份母乳样本进行了溶菌酶浓度和细菌菌落计数测定。平均溶菌酶浓度为21.39±13.19mg/L。早产儿母乳中的溶菌酶浓度（24.99±15.05mg/L）显著高于足月儿母乳（14.89±9.83mg/L）（p<0.05）。细菌菌落计数并未随着溶菌酶浓度的增加而下降，即未发现溶菌酶浓度与细菌计数之间存在相关性。尽管缺乏这种相关性，但观察到溶菌酶浓度与体重增加速率之间存在显著相关性：溶菌酶浓度越高，体重增加越好。这一观察结果的机制仍有待阐明；溶菌酶的营养作用被认为是一种可能的机制。
