Grumach A S, Carmona R C, Lazarotti D, Ribeiro M A, Rozentraub R B, Racz M L, Weinberg A, Carneiro-Sampaio M M
Department of Paediatrics, University of São Paulo, Brazil.
Acta Paediatr. 1993 Mar;82(3):284-90. doi: 10.1111/j.1651-2227.1993.tb12661.x.
Breast milk samples from three groups of Brazilian women were evaluated: G1, mothers delivering term babies of low birth weight (n = 16); G2, mothers delivering preterm babies of appropriate birth weight (n = 20); G3, mothers delivering term babies of appropriate birth weight (n = 30). Milk samples were obtained at 48 h and on the 7th, 15th, 30th and 60th days after delivery and they were analyzed for lysozyme and total IgA levels and for the presence of specific antibodies against Poliovirus types I, II, III, Rotavirus, Herpes simplex virus, Varicella zoster and Cytomegalovirus. The groups were not statistically different in relation to mother's age, parity, type of delivery or socio-economic levels. IgA levels were higher in both low-birth-weight groups (G1 & G2) compared to the control group (G3) throughout the study period. Lysozyme levels decreased up to the 15th day, increasing thereafter up to the 60th day in all groups. Specific antibodies were detected throughout the study period, with no differences among groups. We conclude that breast milk composition of mothers delivering low-birth-weight babies (G1 & G2) was similar despite the different gestational ages.
G1组，分娩低体重足月儿的母亲（n = 16）；G2组，分娩出生体重正常的早产儿的母亲（n = 20）；G3组，分娩出生体重正常的足月儿的母亲（n = 30）。在产后48小时以及产后第7天、15天、30天和60天采集母乳样本，并对其进行溶菌酶和总IgA水平分析，以及检测针对I型、II型、III型脊髓灰质炎病毒、轮状病毒、单纯疱疹病毒、水痘带状疱疹病毒和巨细胞病毒的特异性抗体。在母亲年龄、产次、分娩类型或社会经济水平方面，各组之间无统计学差异。在整个研究期间，两个低体重组（G1和G2）的IgA水平均高于对照组（G3）。在所有组中，溶菌酶水平在第15天之前下降，此后至第60天上升。在整个研究期间均检测到特异性抗体，各组之间无差异。我们得出结论，尽管胎龄不同，但分娩低体重儿的母亲（G1和G2）的母乳成分相似。
