Yosaee Somaye, Soltani Sepideh, Sekhavati Eghbal, Jazayeri Shima
Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Ewaz School of Health, Larestan School of Medical Sciences, Larestan, Iran.
Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2016 Dec;45(12):1568-1576.
Heart disease is one of the most common chronic disease and leading cause of morbidity and mortality worldwide. Adropin, a newly identified protein, is important for energy homeostasis and maintaining insulin sensitivity, and has been referred to as a novel regulator of endothelial cells. Endothelial dysfunction is a key early event in atherogenesis and onset of HD. Therefore, this review gives a systematic overview of studies investigating plasma adropin level in patient with heart disease.
Data carried out in PubMed, Scopus, Web of Science, Embase, Google scholar and MEDLINE, from the earliest available online indexing year through 2015. The search restricted to studies conducted in humans. The keyword search was adropin to apply in title, abstract and keywords. References lists of all original published articles were scanned to find additional eligible studies.
Heart failure (HF), coronary atherosclerosis acute myocardial infarction and Cardiac Syndrome X (CSX) were type of heart disease acknowledged in this study. Majority of evidences introduced low adropin as an independent risk factor of heart disease. In a case-control study, the plasma level of adropin increased with the severity of HF.
Adropinmay be a potential serum biomarker for early diagnosis of HD.
心脏病是全球最常见的慢性病之一，也是发病和死亡的主要原因。Adropin是一种新发现的蛋白质，对能量平衡和维持胰岛素敏感性很重要，被认为是内皮细胞的一种新型调节因子。内皮功能障碍是动脉粥样硬化和心脏病发生的关键早期事件。因此，本综述系统概述了有关研究心脏病患者血浆adropin水平的研究。
在PubMed、Scopus、Web of Science、Embase、谷歌学术和MEDLINE中进行数据检索，时间范围从最早的在线索引年份到2015年。检索仅限于在人类中进行的研究。关键词检索为在标题、摘要和关键词中应用adropin。对所有原始发表文章的参考文献列表进行扫描，以找到其他符合条件的研究。
本研究认可的心脏病类型包括心力衰竭（HF）、冠状动脉粥样硬化、急性心肌梗死和心脏综合征X（CSX）。大多数证据表明低adropin是心脏病的独立危险因素。在一项病例对照研究中，adropin的血浆水平随HF严重程度增加。
Adropin可能是心脏病早期诊断的潜在血清生物标志物。
