Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
Department of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA.
J Physiol. 2021 Feb;599(4):1057-1065. doi: 10.1113/JP280769. Epub 2021 Jan 4.
The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.
因感染 SARS-CoV-2 而导致的 COVID-19 的临床表现变化多样，多数患者症状轻微，而有些患者则发展为严重呼吸衰竭。导致这种差异的原因尚不清楚，亟需研究。一些 COVID-19 患者被贴上了“快乐低氧血症”的标签，这些患者自述呼吸困难，观察到呼吸窘迫的迹象，但实际上并无这些症状。基于目前的讨论，我们重点介绍了可能导致隐匿性低氧血症表现差异的关键呼吸和神经学成分，并确定了后续研究的优先事项。
