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传染性单核细胞增多症中的脾破裂:一例报告

Splenic Rupture in Infectious Mononucleosis: A Case Report.

作者信息

Longi Ahmer A, Edakkavil Zubair, Fazlani Misbah, Rajesh Nambiar, Quraishi Mohammed O

机构信息

Department of Internal Medicine, Mediclinic Welcare Hospital, Dubai, ARE.

Department of Surgery, Mediclinic Welcare Hospital, Dubai, ARE.

出版信息

Cureus. 2025 May 3;17(5):e83438. doi: 10.7759/cureus.83438. eCollection 2025 May.

DOI:10.7759/cureus.83438
PMID:40322602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049665/
Abstract

Splenic ruptures are rarely seen in infectious mononucleosis (IM), caused by the Epstein-Barr virus (EBV). It is a self-limiting viral infection characterized by fever, pharyngitis, and lymphadenopathy. While most cases are mild and resolve without complications, rare and severe complications can arise, including splenic rupture, which is a potentially life-threatening event. Previous case reports have linked splenic rupture to IM with increased splenic size. We present an atypical case report of splenic rupture in a young adult diagnosed with IM, whose spleen was found to be of normal size. This study emphasizes the need for physicians to be more vigilant and closely observe for splenic ruptures in IM patients, despite having normal splenic sizes. This would contribute to reducing both the mortality and morbidity associated with atraumatic splenic ruptures.

摘要

脾破裂在由爱泼斯坦-巴尔病毒(EBV)引起的传染性单核细胞增多症(IM)中很少见。它是一种自限性病毒感染,其特征为发热、咽炎和淋巴结病。虽然大多数病例症状轻微,无需并发症即可痊愈,但也可能出现罕见且严重的并发症,包括脾破裂,这是一种潜在的危及生命的事件。既往病例报告已将脾破裂与脾脏增大的IM病例联系起来。我们报告了一例年轻成人IM患者发生脾破裂的非典型病例,该患者的脾脏大小正常。本研究强调,尽管IM患者的脾脏大小正常,但医生仍需提高警惕,密切观察有无脾破裂情况。这将有助于降低与非创伤性脾破裂相关的死亡率和发病率。

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本文引用的文献

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Splenic rupture or infarction associated with Epstein-Barr virus infectious mononucleosis: a systematic literature review.与 Epstein-Barr 病毒传染性单核细胞增多症相关的脾破裂或梗死:系统文献回顾。
Swiss Med Wkly. 2023 May 17;153:40081. doi: 10.57187/smw.2023.40081.
2
Splenic Infarction: A Rare Complication of Infectious Mononucleosis.脾梗死:传染性单核细胞增多症的一种罕见并发症。
Cureus. 2023 Apr 11;15(4):e37414. doi: 10.7759/cureus.37414. eCollection 2023 Apr.
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Atraumatic splenic rupture in a child with COVID 19.儿童 COVID-19 相关非创伤性脾破裂。
BMC Pediatr. 2022 May 21;22(1):300. doi: 10.1186/s12887-022-03353-8.
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EBV : not your Everyday Benign Virus.爱泼斯坦-巴尔病毒:并非普通的良性病毒。
Acta Gastroenterol Belg. 2020 Jul-Sep;83(3):485-487.
5
A Mysterious Case of an Infarcted Spleen due to Kissing Disease: A Rare Entity.传染性单核细胞增多症导致脾脏梗死的神秘病例:一种罕见情况。
Cureus. 2020 Jan 19;12(1):e6700. doi: 10.7759/cureus.6700.
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Atraumatic splenic rupture after cocaine use and acute Epstein-Barr virus infection: A case report and review of literature.可卡因使用及急性爱泼斯坦-巴尔病毒感染后非创伤性脾破裂:一例报告并文献复习
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Spontaneous splenic rupture in a patient with infectious mononucleosis.传染性单核细胞增多症患者自发性脾破裂。
BMJ Case Rep. 2019 Sep 30;12(9):e230259. doi: 10.1136/bcr-2019-230259.
8
Association of Splenic Rupture and Infectious Mononucleosis: A Retrospective Analysis and Review of Return-to-Play Recommendations.脾破裂与传染性单核细胞增多症的关联:回顾性分析和重返赛场建议的综述。
Sports Health. 2019 Nov/Dec;11(6):543-549. doi: 10.1177/1941738119873665. Epub 2019 Sep 24.
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Epstein-Barr virus and its association with disease - a review of relevance to general practice.爱泼斯坦-巴尔病毒及其与疾病的关联——一篇与全科医学相关的综述。
BMC Fam Pract. 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3.
10
Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus.爱泼斯坦-巴尔病毒引起的急性胃炎和脾梗死
Pediatr Gastroenterol Hepatol Nutr. 2018 Apr;21(2):147-153. doi: 10.5223/pghn.2018.21.2.147. Epub 2018 Apr 13.