Raghuwanshi Kapil, Kushram Bhupesh, Dandotiya Dileep, Petkar Sudhakar, Tambade Swapnali, Gandhe Mahendra
Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India.
Department of Surgery, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India.
Bioinformation. 2025 Feb 28;21(2):116-120. doi: 10.6026/973206300210116. eCollection 2025.
High blood pressure (higher than 140/90 mm Hg), proteinuria and swelling due to fluid retention are symptoms of preeclampsia, a disease that affects pregnant women after the 20th week of pregnancy. The cytoplasm of cells undergoing anaerobic glycolysis contains the enzyme lactate dehydrogenase or LDH. Therefore, it is of interest to ascertain the blood lactate dehydrogenase levels of pre-eclamptic women, to assess and analyze these levels, to compare lactate dehydrogenase levels in different groups of preeclampsia patients and healthy controls and to examine the role of lactate dehydrogenase in preeclampsia severity ratings. Increased blood lactate dehydrogenase levels are associated with more severe preeclampsia, according to this study's results. Thus, it is crucial to determine lactate dehydrogenase levels in pre-eclamptic women early on so that these patients may get the right medicine and reduce the morbidity and mortality associated with these disorders.
高血压（高于140/90毫米汞柱）、蛋白尿以及因液体潴留导致的肿胀是先兆子痫的症状，先兆子痫是一种在妊娠20周后影响孕妇的疾病。进行无氧糖酵解的细胞的细胞质中含有乳酸脱氢酶或LDH。因此，确定先兆子痫女性的血液乳酸脱氢酶水平、评估和分析这些水平、比较不同组先兆子痫患者和健康对照者的乳酸脱氢酶水平以及研究乳酸脱氢酶在先兆子痫严重程度分级中的作用是很有意义的。根据这项研究的结果，血液乳酸脱氢酶水平升高与更严重的先兆子痫相关。因此，尽早测定先兆子痫女性的乳酸脱氢酶水平至关重要，以便这些患者能够得到正确的治疗，并降低与这些疾病相关的发病率和死亡率。
