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缺血性中风后认知障碍中的潜在炎症生物标志物和肠道微生物群差异

Potential Inflammatory Biomarkers and Differential Gut Microbiota in Cognitive Impairment After Ischemic Stroke.

作者信息

Wu Lishuo, Jiang Yajie, Xu Wei, Wang Liwen, Li Liping, Zhang Chunli, Huang Keyu, Yang Yi, Dai Jian, Zhou Fengkun

机构信息

Department of Neurology, The First People's Hospital of Nanning, Nanning, Guangxi, People's Republic of China.

Department of Psychological and Sleep Rehabilitation,Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2025 Apr 28;21:965-972. doi: 10.2147/NDT.S507156. eCollection 2025.

DOI:10.2147/NDT.S507156
PMID:40322725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12047652/
Abstract

OBJECTIVE

Ischemic stroke, one of the main public health problems worldwide, causes a variety of physiological dysfunction, including cognitive impairment. Although studies have been focused on posted-stroke cognitive impairment (PSCI), its pathological mechanism remains unclear.

METHODS

Here, we enrolled 66 participants stratified into three groups: healthy controls (HC, n=15), post-stroke patients without cognitive impairment (PSWCI, n=15), and PSCI patients (n=36). We analyzed clinical parameters and changes of several cytokines and gut microbiota profiles.

RESULTS

We found that compared with healthy control (HC) group, levels of low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), homocysteine (Hcy), CRP and IL-6 were significantly increased in PSWCI and PSCI patients. Of them, levels of Hcy and IL-6 in PSCI group were significantly higher than that in PSWCI. ROC curve analysis identified Hcy and IL-6 as potential diagnostic biomarkers for PSCI. Furthermore, 16S rRNA sequencing of gut microbiota shows that the abundance of and increased, while the abundance of and decreased significantly.

CONCLUSION

These findings suggest that elevated Hcy and IL-6 levels may serve as risk factors for PSCI, with gut microbiota dysregulation potentially contributing to its pathogenesis.

摘要

目的

缺血性中风是全球主要的公共卫生问题之一，会导致多种生理功能障碍，包括认知障碍。尽管已有研究聚焦于中风后认知障碍（PSCI），但其病理机制仍不清楚。

方法

在此，我们招募了66名参与者，分为三组：健康对照组（HC，n = 15）、无认知障碍的中风后患者（PSWCI，n = 15）和PSCI患者（n = 36）。我们分析了临床参数以及几种细胞因子和肠道微生物群谱的变化。

结果

我们发现，与健康对照组（HC）相比，PSWCI和PSCI患者的低密度脂蛋白（LDL）胆固醇、总胆固醇（TC）、同型半胱氨酸（Hcy）、CRP和IL-6水平显著升高。其中，PSCI组的Hcy和IL-6水平显著高于PSWCI组。ROC曲线分析确定Hcy和IL-6为PSCI的潜在诊断生物标志物。此外，肠道微生物群的16S rRNA测序显示，[此处原文可能缺失具体菌种名称]的丰度增加，而[此处原文可能缺失具体菌种名称]的丰度显著降低。

结论

这些发现表明，Hcy和IL-6水平升高可能是PSCI的危险因素，肠道微生物群失调可能在其发病机制中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/36285ee7fb62/NDT-21-965-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/881de165f96c/NDT-21-965-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/f7105c89a89d/NDT-21-965-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/02f97acde2cc/NDT-21-965-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/729be620bfb7/NDT-21-965-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/36285ee7fb62/NDT-21-965-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/881de165f96c/NDT-21-965-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/f7105c89a89d/NDT-21-965-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/02f97acde2cc/NDT-21-965-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/729be620bfb7/NDT-21-965-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fa2/12047652/36285ee7fb62/NDT-21-965-g0005.jpg

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本文引用的文献

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The Effect of Dietary Types on Gut Microbiota Composition and Development of Non-Communicable Diseases: A Narrative Review.膳食类型对肠道微生物组成和非传染性疾病发展的影响：叙述性综述。
Nutrients. 2024 Sep 17;16(18):3134. doi: 10.3390/nu16183134.
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The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is associated with early-onset post-stroke cognitive impairment.HALP（血红蛋白、白蛋白、淋巴细胞和血小板）评分与卒中后早期认知障碍相关。
Neurol Sci. 2023 Jan;44(1):237-245. doi: 10.1007/s10072-022-06414-z. Epub 2022 Oct 4.
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Post-Stroke Cognitive Impairment and Dementia.卒中后认知障碍和痴呆。
Circ Res. 2022 Apr 15;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951. Epub 2022 Apr 14.
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Is There Any Link between Cognitive Impairment and Gut Microbiota? A Systematic Review.认知障碍与肠道微生物群之间有联系吗？系统评价。
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Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment.肠道菌群失调是中风和认知障碍的危险因素之一，也是潜在的治疗靶点。
Pharmacol Res. 2021 Feb;164:105277. doi: 10.1016/j.phrs.2020.105277. Epub 2020 Nov 7.
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