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膳食类型对肠道微生物组成和非传染性疾病发展的影响:叙述性综述。

The Effect of Dietary Types on Gut Microbiota Composition and Development of Non-Communicable Diseases: A Narrative Review.

机构信息

Institute of Hygiene, Faculty of Medicine, Comenius University in Bratislava, Špitálska 24, 813 72 Bratislava, Slovakia.

出版信息

Nutrients. 2024 Sep 17;16(18):3134. doi: 10.3390/nu16183134.


DOI:10.3390/nu16183134
PMID:39339734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434870/
Abstract

INTRODUCTION: The importance of diet in shaping the gut microbiota is well established and may help improve an individual's overall health. Many other factors, such as genetics, age, exercise, antibiotic therapy, or tobacco use, also play a role in influencing gut microbiota. AIM: This narrative review summarizes how three distinct dietary types (plant-based, Mediterranean, and Western) affect the composition of gut microbiota and the development of non-communicable diseases (NCDs). METHODS: A comprehensive literature search was conducted using the PubMed, Web of Science, and Scopus databases, focusing on the keywords "dietary pattern", "gut microbiota" and "dysbiosis". RESULTS: Both plant-based and Mediterranean diets have been shown to promote the production of beneficial bacterial metabolites, such as short-chain fatty acids (SCFAs), while simultaneously lowering concentrations of trimethylamine-N-oxide (TMAO), a molecule associated with negative health outcomes. Additionally, they have a positive impact on microbial diversity and therefore are generally considered healthy dietary types. On the other hand, the Western diet is a typical example of an unhealthy nutritional approach leading to an overgrowth of pathogenic bacteria, where TMAO levels rise and SCFA production drops due to gut dysbiosis. CONCLUSION: The current scientific literature consistently highlights the superiority of plant-based and Mediterranean dietary types over the Western diet in promoting gut health and preventing NCDs. Understanding the influence of diet on gut microbiota modulation may pave the way for novel therapeutic strategies.

摘要

简介:饮食对肠道微生物群的形成起着重要作用,它可以帮助改善个体的整体健康状况。许多其他因素,如遗传、年龄、运动、抗生素治疗或吸烟,也在影响肠道微生物群方面发挥作用。

目的:本综述总结了三种不同的饮食类型(植物性饮食、地中海饮食和西方饮食)如何影响肠道微生物群的组成和非传染性疾病(NCD)的发展。

方法:通过 PubMed、Web of Science 和 Scopus 数据库进行了全面的文献检索,重点使用了“饮食模式”、“肠道微生物群”和“肠道失调”这三个关键词。

结果:植物性饮食和地中海饮食都被证明可以促进有益细菌代谢产物的产生,如短链脂肪酸(SCFAs),同时降低与负面健康结果相关的三甲胺-N-氧化物(TMAO)的浓度。此外,它们对微生物多样性有积极影响,因此通常被认为是健康的饮食类型。另一方面,西方饮食是一种典型的不健康营养方式,导致致病菌过度生长,其中 TMAO 水平上升,由于肠道失调,SCFA 产生下降。

结论:目前的科学文献一致强调,植物性饮食和地中海饮食在促进肠道健康和预防 NCD 方面优于西方饮食。了解饮食对肠道微生物群调节的影响可能为新的治疗策略铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8d/11434870/1e940840acf3/nutrients-16-03134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8d/11434870/1e940840acf3/nutrients-16-03134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8d/11434870/1e940840acf3/nutrients-16-03134-g001.jpg

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[3]
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Front Nutr. 2025-8-1

[4]
Individualized Diets in Patients with Kidney Disease and Kidney Transplants: A Narrative Review.

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[5]
Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health.

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[6]
Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease.

J Fungi (Basel). 2025-4-22

[7]
Dietary index for gut microbiota and risk of gastrointestinal cancer: a prospective gene-diet study.

Nutr J. 2025-5-17

[8]
Could a Mediterranean Diet Modulate Alzheimer's Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration.

Foods. 2025-4-29

[9]
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection.

Int J Mol Sci. 2025-4-15

[10]
Potential Inflammatory Biomarkers and Differential Gut Microbiota in Cognitive Impairment After Ischemic Stroke.

Neuropsychiatr Dis Treat. 2025-4-28

本文引用的文献

[1]
The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management-A Narrative Review.

Nutrients. 2024-8-2

[2]
Effect of Fiber-Rich Diet and Rope Skipping on Memory, Executive Function, and Gut Microbiota in Young Adults: A Randomized Controlled Trial.

Mol Nutr Food Res. 2024-2

[3]
Human microbiome myths and misconceptions.

Nat Microbiol. 2023-8

[4]
The Effects of the Mediterranean Diet on Health and Gut Microbiota.

Nutrients. 2023-4-29

[5]
Isha yoga practices, vegan diet, and participation in Samyama meditation retreat: impact on the gut microbiome & metabolome - a non-randomized trial.

BMC Complement Med Ther. 2023-4-5

[6]
Effect of Plant-Based Diets on Gut Microbiota: A Systematic Review of Interventional Studies.

Nutrients. 2023-3-21

[7]
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?

Int J Mol Sci. 2023-1-18

[8]
The Microbiota-Gut-Brain Axis in Psychiatric Disorders.

Int J Mol Sci. 2022-9-24

[9]
Gut microbiota, inflammatory bowel disease and colorectal cancer.

World J Gastroenterol. 2022-8-14

[10]
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.

Microorganisms. 2022-9-18

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