Oyelayo Emmanuel Adedeji, Taiwo Tayo John, Oyelude Samuel Oyeponle, Alao Jude Oluwapelumi
Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Nigeria.
Department of Medicine, Ladoke Akintola University of Technology, Ogbomosho, Nigeria.
Environ Monit Assess. 2025 May 5;197(6):625. doi: 10.1007/s10661-025-14086-3.
This study examines the relationship between industrialisation, climate change, and antimicrobial resistance (AMR) gene prevalence. Data analysis from the top 20 highly industrialised and the top 20 least industrialised nations revealed that industrial activities significantly contribute to global warming, with temperature increases of up to 2 °C observed in highly industrialised regions. These environmental changes influence the distribution and evolution of AMR genes, as rising temperatures can affect bacterial resistance in a manner similar to antibiotics. Through a bioinformatics approach, a marked disparity in AMR gene frequencies was observed between highly industrialised and less industrialised nations, with developed countries reporting higher frequencies due to extensive antibiotic use and advanced monitoring systems. 'Eco-AMR Zones' is proposed as a solution to specialised areas by promoting sustainable industrial practices, enforcing pollution controls, and regulating antibiotic use to mitigate AMR's environmental and public health impacts. These zones, supported by collaboration across various sectors, offer a promising approach to preserving antibiotic effectiveness and reducing environmental degradation. The study emphasises the importance of integrated global strategies that address both the ecological and public health challenges posed by AMR, advocating for sustainable practices, international collaboration, and ongoing research to combat the evolving threats of climate change and antimicrobial resistance.
本研究考察了工业化、气候变化与抗菌药物耐药性（AMR）基因流行率之间的关系。对排名前20的高度工业化国家和排名前20的工业化程度最低的国家进行数据分析后发现，工业活动对全球变暖有显著影响，在高度工业化地区观测到气温上升高达2摄氏度。这些环境变化影响了AMR基因的分布和演变，因为气温上升对细菌耐药性的影响方式与抗生素类似。通过生物信息学方法，在高度工业化国家和工业化程度较低的国家之间观察到AMR基因频率存在显著差异，发达国家由于抗生素的广泛使用和先进的监测系统而报告了更高的频率。“生态AMR区”被提议作为针对特定区域的解决方案，通过促进可持续工业实践、加强污染控制和规范抗生素使用，以减轻AMR对环境和公共卫生的影响。这些区域在各部门合作的支持下，为保持抗生素有效性和减少环境退化提供了一种有前景的方法。该研究强调了综合全球战略的重要性，这些战略要应对AMR带来的生态和公共卫生挑战，倡导可持续实践、国际合作以及持续研究，以应对气候变化和抗菌药物耐药性不断演变的威胁。
