Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.
Department of Exercise Physiology, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.
Trials. 2023 Aug 12;24(1):519. doi: 10.1186/s13063-023-07553-0.
Exercise training is a major factor in controlling type 1 diabetes mellitus (T1DM) in children. The present study aimed to assess the effect of concurrent resistance-aerobic training on selected inflammatory factors and hormones related to blood glucose homeostasis in children with T1DM.
In this randomized controlled clinical trial, 40 children (with the mean age of 11.11 ± 2.29 years) were randomly assigned to an experimental (N = 20) or control group (N = 20). They underwent a 16-week training program, composed of concurrent resistance-aerobic training performed intermittently for 60 min three times a week. Before and after training, blood samples were analyzed for glucose homeostasis, selected inflammatory factors, and growth factors. Data were analyzed by paired t-test and analysis of covariance (ANCOVA) in IBM SPSS version 22.
The exercise training intervention reduced fasting blood sugar index (P = 0.002) and glycosylated hemoglobin significantly (P = 0.003). The growth hormone levels were increased significantly only in the experimental group (P = 0.037), whereas no significant difference was noted in the insulin-like growth factor-1 (P = 0.712). It was also found that interleukin-1β and high-sensitivity C-reactive protein did not change in the experimental or control group as compared to the pretest (P > 0.05).
As it was shown, it seems that concurrent resistance-aerobic training may improve blood glucose homeostasis and growth hormone. Therefore, these findings may suggest the benefit from exercise training of moderate intensity in children with T1DM. Besides, we recommend undertaking further clinical trials to determine if the exercise training was effective.
This study was registered in the Iranian Registry of Clinical Trials under the code IRCT20150531022498N30: https://en.irct.ir/trial/41031 . Registered on July 26, 2019. All experiments on the participants were following the Declaration of Helsinki.
运动训练是控制儿童 1 型糖尿病（T1DM）的主要因素。本研究旨在评估同时进行抗阻-有氧训练对 T1DM 儿童血糖稳态相关的某些炎症因子和激素的影响。
在这项随机对照临床试验中，40 名儿童（平均年龄为 11.11±2.29 岁）被随机分为实验组（n=20）或对照组（n=20）。他们接受了为期 16 周的训练计划，包括每周三次、每次 60 分钟的间歇性抗阻-有氧训练。在训练前后，分析了血糖稳态、选定的炎症因子和生长因子的血液样本。数据采用 IBM SPSS 版本 22 的配对 t 检验和协方差分析（ANCOVA）进行分析。
运动训练干预显著降低了空腹血糖指数（P=0.002）和糖化血红蛋白（P=0.003）。实验组生长激素水平显著升高（P=0.037），而胰岛素样生长因子-1（P=0.712）则无显著差异。此外，与试验前相比，实验组和对照组的白细胞介素-1β和高敏 C 反应蛋白均无变化（P>0.05）。
正如研究结果所示，同时进行抗阻-有氧训练可能改善血糖稳态和生长激素。因此，这些发现表明，对于 T1DM 儿童，进行适度强度的运动训练可能有益。此外，我们建议进行进一步的临床试验，以确定运动训练是否有效。
本研究在伊朗临床试验注册中心注册，注册号为 IRCT20150531022498N30：https://en.irct.ir/trial/41031。于 2019 年 7 月 26 日注册。所有对参与者的实验均遵循《赫尔辛基宣言》。
