Sim Julius, Smith Louise E, Amlôt Richard, Rubin G James, Sevdalis Nick, Sherman Susan M
School of Medicine, Keele University, Keele, United Kingdom.
Behavioural Science and Insights Unit, United Kingdom Health Security Agency, London, United Kingdom.
PLoS One. 2025 May 5;20(5):e0322503. doi: 10.1371/journal.pone.0322503. eCollection 2025.
When developing public health measures in a pandemic, it is important to examine attitudes and beliefs relating to vaccination uptake. We report the discrimination of a single-item vaccination intention scale and derive cutpoints in terms of sensitivity (true positives) and specificity (true negatives) in relation to subsequent vaccination status.
In a sample of UK adults (n=1119) recruited through an online survey platform, vaccination intention was measured on a 0-10 numerical rating scale (0=very unlikely, 10=very likely) at the beginning of the UK COVID-19 vaccination rollout (January 2021), and self-reported vaccination status was gathered after vaccination had been offered to all adults (October 2021). Discrimination of the scale was measured by the area under the receiver operating characteristic (ROC) curve.
The responders reporting being vaccinated or unvaccinated were 1034 (92.4%) and 85 (7.6%), respectively. The area under the ROC curve was.956 (95% CI.943,.967), indicating a high degree of discrimination. The combined value of sensitivity and specificity was greatest at a cutpoint of 8 on the scale (sensitivity =.821, specificity =.988). If, however, the individual values of sensitivity and specificity are required to be simultaneously optimized, this occurs at point 6 (sensitivity =.886, specificity =.871).
We recommend a 0-10 intention scale as a validated, practical measure of vaccination intention in public health practice, with a cutpoint of 8 on the scale as optimal, unless sensitivity and specificity are to be simultaneously optimized, when 6 is the optimal cutpoint.
在大流行期间制定公共卫生措施时,审视与疫苗接种接受度相关的态度和信念很重要。我们报告了单项疫苗接种意愿量表的区分度,并根据与后续疫苗接种状况相关的敏感度(真阳性)和特异度(真阴性)得出切点。
通过在线调查平台招募了1119名英国成年人作为样本,在英国新冠疫苗接种计划开始时(2021年1月),用0至10的数字评分量表(0=极不可能,10=极有可能)测量疫苗接种意愿,并在向所有成年人提供疫苗接种后(2021年10月)收集自我报告的疫苗接种状况。该量表的区分度通过受试者工作特征(ROC)曲线下面积来衡量。
报告已接种或未接种疫苗的应答者分别为1034人(92.4%)和85人(7.6%)。ROC曲线下面积为0.956(95%置信区间0.943,0.967),表明区分度很高。量表上的切点为8时,敏感度和特异度的综合值最大(敏感度=0.821,特异度=0.988)。然而,如果需要同时优化敏感度和特异度的个体值,则在切点为6时出现(敏感度=0.886,特异度=0.871)。
我们建议使用0至10的意愿量表作为公共卫生实践中经过验证的、实用的疫苗接种意愿衡量指标,量表上的切点为8时最佳,除非要同时优化敏感度和特异度,此时切点为6是最佳选择。