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Refining the role of the paraventricular hypothalamus in feeding behavior.

作者信息

Fang Lisa Z, Hirasawa Michiru

机构信息

Department of Anesthesiology, Washington University in St Louis, St Louis, MO 63110.

Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.

出版信息

Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2506038122. doi: 10.1073/pnas.2506038122. Epub 2025 May 5.

DOI:10.1073/pnas.2506038122
PMID:40324098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12088438/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8690/12088438/877237ce7acc/pnas.2506038122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8690/12088438/877237ce7acc/pnas.2506038122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8690/12088438/877237ce7acc/pnas.2506038122fig01.jpg

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本文引用的文献

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Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.下丘脑室旁核中的多巴胺能神经元会延长食物消耗阶段。
Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2411069122. doi: 10.1073/pnas.2411069122. Epub 2025 Mar 28.
2
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.AgRP 和 POMC 神经元的相互作用控制摄食和代谢的协调控制。
Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20.
3
Unraveling the dynamics of dopamine release and its actions on target cells.
解析多巴胺释放及其对靶细胞作用的动态变化。
Trends Neurosci. 2023 Mar;46(3):228-239. doi: 10.1016/j.tins.2022.12.005. Epub 2023 Jan 10.
4
Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior.基底前脑到外侧缰核回路的激活驱动反射性厌恶并抑制进食行为。
Sci Rep. 2022 Dec 21;12(1):22044. doi: 10.1038/s41598-022-26306-8.
5
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding.食欲行为:控制摄食、饱食和终止阶段的神经回路。
Nat Metab. 2022 Jul;4(7):836-847. doi: 10.1038/s42255-022-00611-y. Epub 2022 Jul 25.
6
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.室旁核通过两个遗传上不同的回路调节饱腹感并预防肥胖。
Neuron. 2019 May 8;102(3):653-667.e6. doi: 10.1016/j.neuron.2019.02.028. Epub 2019 Mar 14.
7
Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.定义的室旁下丘脑群体表现出对食物的不同反应,具体取决于热量状态。
Cell Metab. 2019 Mar 5;29(3):681-694.e5. doi: 10.1016/j.cmet.2018.10.016. Epub 2018 Nov 21.
8
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward.外侧下丘脑区谷氨酸能神经元及其向外侧缰核的投射调节进食与奖赏。
J Neurosci. 2016 Jan 13;36(2):302-11. doi: 10.1523/JNEUROSCI.1202-15.2016.
9
Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.Sim1神经元中的Dnmt3a对于正常能量稳态是必需的。
J Neurosci. 2014 Nov 12;34(46):15288-96. doi: 10.1523/JNEUROSCI.1316-14.2014.
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Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.化学遗传突触沉默神经回路将下丘脑→中脑通路定位用于摄食行为。
Neuron. 2014 May 21;82(4):797-808. doi: 10.1016/j.neuron.2014.04.008. Epub 2014 Apr 24.