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Refining the role of the paraventricular hypothalamus in feeding behavior.

作者信息

Fang Lisa Z, Hirasawa Michiru

机构信息

Department of Anesthesiology, Washington University in St Louis, St Louis, MO 63110.

Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL A1B 3V6, Canada.

出版信息

Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2506038122. doi: 10.1073/pnas.2506038122. Epub 2025 May 5.

Abstract
摘要

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本文引用的文献

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Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.
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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.
Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20.
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Unraveling the dynamics of dopamine release and its actions on target cells.
Trends Neurosci. 2023 Mar;46(3):228-239. doi: 10.1016/j.tins.2022.12.005. Epub 2023 Jan 10.
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Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding.
Nat Metab. 2022 Jul;4(7):836-847. doi: 10.1038/s42255-022-00611-y. Epub 2022 Jul 25.
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The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.
Neuron. 2019 May 8;102(3):653-667.e6. doi: 10.1016/j.neuron.2019.02.028. Epub 2019 Mar 14.
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Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.
Cell Metab. 2019 Mar 5;29(3):681-694.e5. doi: 10.1016/j.cmet.2018.10.016. Epub 2018 Nov 21.
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Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.
J Neurosci. 2014 Nov 12;34(46):15288-96. doi: 10.1523/JNEUROSCI.1316-14.2014.
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Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.
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