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针对生物恐怖主义和化学战的医疗准备:一项公共卫生整合综述。

Medical preparedness for bioterrorism and chemical warfare: A public health integration review.

作者信息

Ugwu Chinyere N, Ugwu Okechukwu Paul-Chima, Alum Esther Ugo, Eze Val Hyginus Udoka, Basajja Mariam, Ugwu Jovita Nnenna, Ogenyi Fabian C, Ejemot-Nwadiaro Regina Idu, Okon Michael Ben, Egba Simeon Ikechukwu, Uti Daniel Ejim

机构信息

Department of Publication and Extension, Kampala International University, Kampala, Uganda.

Health Care and Data Management Leiden University, Kampala, Uganda.

出版信息

Medicine (Baltimore). 2025 May 2;104(18):e42289. doi: 10.1097/MD.0000000000042289.

DOI:10.1097/MD.0000000000042289
PMID:40324267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12055186/
Abstract

Global public health faces a major danger from chemical and biological weapon-related terrorism which requires comprehensive emergency preparedness and response strategies. This review investigates present-day public health measures against bioterrorism by focusing on an all-hazards framework which unifies traditional and nontraditional threats. The review evaluates federal programs that boost state and local health systems through funding, distribution and team-based partnerships and technological innovation. The primary emergency response elements consist of identifying outbreaks early and improving surveillance together with using state-of-the-art diagnostic tools to detect biological and chemical agents. The review emphasizes the necessity of maintaining healthcare provider education alongside preparations of full medical readiness plans as well as strategic approaches for safeguarding defenseless groups. This paper investigates resource constraints and governmental agency coordination challenges during biowarfare emergencies. The review examines nucleic-acid-based diagnostic and sensor network innovations as vital components for real-time biological agent detection systems. The review emphasizes the vital role of community involvement together with psychological resistance training in addition to continued pathogen behavior study and protection research. The review demonstrates that successful bioterrorism risk reduction depends on advanced integrated protection strategies which combine state agency collaboration with state of the art monitoring techniques and strengthened public health systems.

摘要

全球公共卫生面临与化学和生物武器相关的恐怖主义带来的重大危险,这需要全面的应急准备和应对策略。本综述通过关注一个统一传统和非传统威胁的全灾种框架,来研究当今针对生物恐怖主义的公共卫生措施。该综述评估了通过资金、物资分配以及基于团队的伙伴关系和技术创新来加强州和地方卫生系统的联邦项目。主要的应急响应要素包括早期识别疫情、改进监测,以及使用最先进的诊断工具来检测生物和化学制剂。该综述强调,在制定全面的医疗准备计划的同时,保持对医疗保健提供者的教育,以及保护弱势群体的战略方法的必要性。本文研究了生物战紧急情况期间的资源限制和政府机构协调挑战。该综述将基于核酸的诊断和传感器网络创新视为实时生物制剂检测系统的重要组成部分进行了考察。该综述强调了社区参与、心理抵抗训练以及持续的病原体行为研究和防护研究的重要作用。该综述表明,成功降低生物恐怖主义风险取决于先进的综合保护策略,这些策略将州机构合作与最先进的监测技术以及强化的公共卫生系统相结合。

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Evaluation of whole and core genome multilocus sequence typing allele schemes for outbreak detection in a national surveillance network, PulseNet USA.美国国家食源疾病监测网络PulseNet中用于暴发检测的全基因组和核心基因组多位点序列分型等位基因方案评估
Front Microbiol. 2023 Sep 21;14:1254777. doi: 10.3389/fmicb.2023.1254777. eCollection 2023.
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Reducing Vaccination Disparities During a National Emergency Response: The US Mpox Vaccine Equity Pilot Program.在国家应急响应期间减少疫苗接种差距:美国猴痘疫苗公平试点计划。
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