Vara-Pérez Mónica, Movahedi Kiavash
Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Immunity. 2025 May 13;58(5):1085-1100. doi: 10.1016/j.immuni.2025.04.005. Epub 2025 May 4.
The brain's border tissues serve as essential hubs for neuroimmune regulation and the trafficking of biomaterials to and from the brain. These complex tissues-including the meninges, perivascular spaces, choroid plexus, and circumventricular organs-balance the brain's need for immune privilege with immune surveillance and blood-brain communication. Macrophages are integral components of these tissues, taking up key strategic positions within the brain's circulatory system. These border-associated macrophages, or "BAMs," are therefore emerging as pivotal for brain homeostasis and disease. BAMs perform trophic functions that help to support border homeostasis but also act as immune sentinels essential for border defense. In this review, we integrate recent findings on BAM origins, cell states, and functions, aiming to provide global insights and perspectives on the complex relationship between these macrophages and their border niche.
大脑的边界组织是神经免疫调节以及生物材料进出大脑运输的重要枢纽。这些复杂的组织包括脑膜、血管周围间隙、脉络丛和室周器官，它们在大脑对免疫豁免的需求与免疫监视及血脑通讯之间取得平衡。巨噬细胞是这些组织的重要组成部分，在大脑循环系统中占据关键的战略位置。因此，这些与边界相关的巨噬细胞，即“BAM”，正逐渐成为大脑内环境稳态和疾病的关键因素。BAM执行营养功能以支持边界内环境稳态，同时还作为边界防御必不可少的免疫哨兵。在这篇综述中，我们整合了关于BAM起源、细胞状态和功能的最新研究结果，旨在全面深入地了解这些巨噬细胞与其边界微环境之间的复杂关系并提供相关观点。
