Rebolledo Laura P, Andrade Luciana N S, Bajgelman Marcio C, Banks Lawrence, Breakefield Xandra O, Dobrovolskaia Marina A, Dokholyan Nikolay V, Kimura Edna T, Villa Luisa, Zerbini Luiz F, Zucolotto Valtencir, Afonin Kirill A, Strauss Bryan E, Chammas Roger, de Freitas Saito Renata
Chemistry and Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC, USA.
Center for Translational Research in Oncology (LIM/24), Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Nanomedicine (Lond). 2025 Jun;20(11):1281-1298. doi: 10.1080/17435889.2025.2501919. Epub 2025 May 6.
Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.
由于不同癌症具有多样的生物学行为以及重大的治疗障碍，它们仍然是全球主要的健康挑战。人口老龄化和生活方式因素增加了癌症的发病率，给医疗保健系统带来了越来越大的压力。尽管不断取得进展，但由于晚期诊断、肿瘤异质性和耐药性，许多癌症仍然是致命的，因此迫切需要开发创新的治疗方案。治疗性核酸作为一类新型生物药物，为克服这些挑战提供了一种有前景的方法。最近召开的癌症治疗诊断中的核酸与纳米生物系统（NANCT）会议汇聚了来自15个国家的国际知名专家，讨论前沿研究，内容涵盖从溶瘤病毒到抗癌RNA纳米颗粒以及其他新兴纳米技术。本综述总结了关键见解和进展，强调了将科学进步跨学科转化为临床实践的必要性，并塑造个性化癌症治疗的未来以改善治疗效果。
