Luo QingQing, Yu Li
Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Provincial Key Laboratory of Hematological Diseases (2024SSY06052), Nanchang, Jiangxi, China.
Discov Oncol. 2025 May 6;16(1):671. doi: 10.1007/s12672-025-02517-z.
Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and is closely associated with myeloid malignancies as well as various non-malignant diseases. This study aims to explore the research trends and hotspots of CH using bibliometric analysis.
Relevant studies were retrieved from the Web of Science Core Collection database based on predefined inclusion criteria. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and R software.
A total of 851 studies were included. From 2014 to 2024, the annual number of publications showed a consistent upward trend. The United States was identified as the leading country in this field, contributing 53.7% of the total publications. Harvard Medical School and Benjamin L Ebert were recognized as the most influential institution and author, respectively. Blood was the most prolific journal, with the highest citation and H-index. Research on CH-related gene mutations and their association with the risk of acute myeloid leukemia is currently the most extensively studied area, while cardiovascular diseases and inflammation have emerged as recent research hotspots.
This study is the first to systematically analyze research related to CH using bibliometric methods. Our analysis reveals the overall landscape of CH research and identifies the most influential contributors in the field, including countries, institutions, authors, and journals. Moreover, we identify emerging research hotspots and key areas, highlighting potential avenues for exploration and innovation within the field of CH.
克隆性造血（CH）是指由体细胞突变引起的造血干细胞克隆性扩增。CH在老年人中普遍存在，与髓系恶性肿瘤以及各种非恶性疾病密切相关。本研究旨在通过文献计量分析探讨CH的研究趋势和热点。
根据预先设定的纳入标准，从Web of Science核心合集数据库中检索相关研究。使用VOSviewer、CiteSpace和R软件进行文献计量分析和可视化。
共纳入851项研究。2014年至2024年，年发表量呈持续上升趋势。美国被确定为该领域的领先国家，占总发表量的53.7%。哈佛医学院和本杰明·L·埃伯特分别被认为是最具影响力的机构和作者。《血液》是发文量最多的期刊，具有最高的引用率和H指数。目前，关于CH相关基因突变及其与急性髓系白血病风险的关联是研究最广泛的领域，而心血管疾病和炎症已成为近期的研究热点。
本研究首次使用文献计量方法系统分析与CH相关的研究。我们的分析揭示了CH研究的整体格局，并确定了该领域最具影响力的贡献者，包括国家、机构、作者和期刊。此外，我们还确定了新兴的研究热点和关键领域，突出了CH领域内潜在的探索和创新途径。
