通过脑脊液宏基因组下一代测序在心脏移植患者中诊断出查加斯脑膜脑炎。
Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.
作者信息
Teitelbaum Jill, Madan Shivank, Patel Snehal, Coyle Christina, Chiu Charles Y, Thwe Phyu M, Uehara Mayuko, Jermyn Rita, Hemmige Vagish
机构信息
Albert Einstein College of Medicine, Bronx, New York.
Montefiore Medical Center, Bronx, New York.
出版信息
Am J Trop Med Hyg. 2025 May 6;113(1):32-36. doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.
Abstract
Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.
摘要
恰加斯脑膜脑炎可出现在器官移植后的免疫功能低下患者中。我们报告了首例通过脑脊液宏基因组下一代测序（mNGS）诊断出恰加斯脑膜脑炎的病例。该病例中恰加斯病的诊断突出了mNGS在识别罕见或意外病原体方面的作用。
相似文献
1
Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.通过脑脊液宏基因组下一代测序在心脏移植患者中诊断出查加斯脑膜脑炎。
Am J Trop Med Hyg. 2025 May 6;113(1):32-36. doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.
2
Chagasic meningoencephalitis with detection of Trypanosoma cruzi in the cerebrospinal fluid of an immunodepressed patient.免疫抑制患者脑脊液中检测到克氏锥虫的查加斯脑膜脑炎
J Trop Med Hyg. 1994 Dec;97(6):367-70.
3
Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time?宏基因组下一代测序在儿童脑炎中病毒的脑脊液分析：尚未准备好投入使用？
J Child Neurol. 2021 Apr;36(5):350-356. doi: 10.1177/0883073820972232. Epub 2020 Nov 18.
4
Clinical value of metagenomic next-generation sequencing in screening oropharyngeal colonization in patients undergoing allogeneic hematopoietic stem cell transplantation: a prospective observational study.宏基因组下一代测序在异基因造血干细胞移植患者口咽定植筛查中的临床价值：一项前瞻性观察研究。
Microbiol Spectr. 2025 Jul;13(7):e0002825. doi: 10.1128/spectrum.00028-25. Epub 2025 May 27.
5
Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area.元基因组下一代测序在布氏菌病诊断中的应用：来自非流行区的 5 例报告。
Future Microbiol. 2024 Sep;19(13):1111-1117. doi: 10.1080/17460913.2024.2363632. Epub 2024 Aug 7.
6
Chagasic meningoencephalitis: case report of a recently included AIDS-defining illness in Brazil.恰加斯病性脑膜脑炎：巴西近期纳入的艾滋病定义疾病病例报告。
Rev Inst Med Trop Sao Paulo. 2004 Jul-Aug;46(4):199-202. doi: 10.1590/s0036-46652004000400005. Epub 2004 Sep 3.
7
Triatoma dimidiata, domestic animals and acute Chagas disease: a 10-year follow-up after an eco-bio-social intervention.二点锥猎蝽、家畜与急性恰加斯病：生态 - 生物 - 社会干预后的10年随访
Parasit Vectors. 2025 Jul 4;18(1):253. doi: 10.1186/s13071-025-06897-7.
8
Diagnosis of invasive pulmonary aspergillosis using metagenomic next-generation sequencing and conventional microbial tests post-COVID-19 pandemic.在新冠疫情后使用宏基因组下一代测序和传统微生物检测诊断侵袭性肺曲霉病
Microbiol Spectr. 2025 Jul;13(7):e0012125. doi: 10.1128/spectrum.00121-25. Epub 2025 Jun 9.
9
Real-world pathogen diagnosis in critically ill infected children: A retrospective study using metagenomic next-generation sequencing with different enrichment strategies.危重症感染儿童的真实世界病原体诊断：一项使用宏基因组下一代测序及不同富集策略的回顾性研究
J Infect Public Health. 2025 Aug;18(8):102823. doi: 10.1016/j.jiph.2025.102823. Epub 2025 May 11.
10
Consistency between metagenomic next-generation sequencing versus traditional microbiological tests for infective disease: systemic review and meta-analysis.宏基因组下一代测序与传统微生物学检测在感染性疾病诊断中的一致性：系统评价与荟萃分析。
Crit Care. 2025 Feb 3;29(1):55. doi: 10.1186/s13054-025-05288-9.
本文引用的文献
1
Chagas Disease in People with HIV: A Narrative Review.HIV感染者中的恰加斯病：一项叙述性综述
Trop Med Infect Dis. 2021 Nov 9;6(4):198. doi: 10.3390/tropicalmed6040198.
2
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.临床宏基因组测序在脑膜炎和脑炎诊断中的应用。
N Engl J Med. 2019 Jun 13;380(24):2327-2340. doi: 10.1056/NEJMoa1803396.
3
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid.临床宏基因组测序检测脑脊液病原体的实验室验证。
Genome Res. 2019 May;29(5):831-842. doi: 10.1101/gr.238170.118. Epub 2019 Apr 16.
4
Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.实体器官移植受者的组织和血液原生动物感染，包括弓形虫病、恰加斯病、利什曼病、巴贝虫病、棘阿米巴病、巴尔通体病和福氏耐格里阿米巴，美国移植感染病学会实践社区指南。
Clin Transplant. 2019 Sep;33(9):e13546. doi: 10.1111/ctr.13546. Epub 2019 Apr 29.
5
Diagnosis of Meningitis Caused by Pathogenic Microorganisms Using Magnetic Resonance Imaging: A Systematic Review.利用磁共振成像诊断致病性微生物引起的脑膜炎：一项系统评价。
Basic Clin Neurosci. 2018 Mar-Apr;9(2):73-86. doi: 10.29252/nirp.bcn.9.2.73.
6
Chagas Disease Recommendations for Solid-Organ Transplant Recipients and Donors.恰加斯病：实体器官移植受者和供者的建议
Transplantation. 2018 Feb;102(2S Suppl 2):S1-S7. doi: 10.1097/TP.0000000000002019.
7
Central nervous system syndromes in solid organ transplant recipients.实体器官移植受者的中枢神经系统综合征。
Clin Infect Dis. 2014 Oct;59(7):1001-11. doi: 10.1093/cid/ciu428. Epub 2014 Jun 9.
8
Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome.一名获得性免疫缺陷综合征患者的克氏锥虫性脑膜脑炎
Am J Trop Med Hyg. 2014 Jul;91(1):84-5. doi: 10.4269/ajtmh.14-0058. Epub 2014 Jun 2.
9
Heart transplantation for Chagas cardiomyopathy in the United States.美国的克山病心肌病心脏移植。
Am J Transplant. 2013 Dec;13(12):3262-8. doi: 10.1111/ajt.12507. Epub 2013 Oct 28.
10
Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas.非流行地区器官和造血组织移植项目中恰加斯病管理的建议。
Transplant Rev (Orlando). 2011 Jul;25(3):91-101. doi: 10.1016/j.trre.2010.12.002. Epub 2011 Apr 29.
Zotero 插件