通过脑脊液宏基因组下一代测序在心脏移植患者中诊断出查加斯脑膜脑炎。
Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.
作者信息
Teitelbaum Jill, Madan Shivank, Patel Snehal, Coyle Christina, Chiu Charles Y, Thwe Phyu M, Uehara Mayuko, Jermyn Rita, Hemmige Vagish
机构信息
Albert Einstein College of Medicine, Bronx, New York.
Montefiore Medical Center, Bronx, New York.
出版信息
Am J Trop Med Hyg. 2025 May 6;113(1):32-36. doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.
Abstract
Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.
摘要
恰加斯脑膜脑炎可出现在器官移植后的免疫功能低下患者中。我们报告了首例通过脑脊液宏基因组下一代测序（mNGS）诊断出恰加斯脑膜脑炎的病例。该病例中恰加斯病的诊断突出了mNGS在识别罕见或意外病原体方面的作用。
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