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Am J Trop Med Hyg. 2025 May 6;113(1):32-36. doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.
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J Trop Med Hyg. 1994 Dec;97(6):367-70.
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本文引用的文献

1
Chagas Disease in People with HIV: A Narrative Review.HIV感染者中的恰加斯病：一项叙述性综述
Trop Med Infect Dis. 2021 Nov 9;6(4):198. doi: 10.3390/tropicalmed6040198.
2
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.临床宏基因组测序在脑膜炎和脑炎诊断中的应用。
N Engl J Med. 2019 Jun 13;380(24):2327-2340. doi: 10.1056/NEJMoa1803396.
3
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid.临床宏基因组测序检测脑脊液病原体的实验室验证。
Genome Res. 2019 May;29(5):831-842. doi: 10.1101/gr.238170.118. Epub 2019 Apr 16.
4
Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.实体器官移植受者的组织和血液原生动物感染，包括弓形虫病、恰加斯病、利什曼病、巴贝虫病、棘阿米巴病、巴尔通体病和福氏耐格里阿米巴，美国移植感染病学会实践社区指南。
Clin Transplant. 2019 Sep;33(9):e13546. doi: 10.1111/ctr.13546. Epub 2019 Apr 29.
5
Diagnosis of Meningitis Caused by Pathogenic Microorganisms Using Magnetic Resonance Imaging: A Systematic Review.利用磁共振成像诊断致病性微生物引起的脑膜炎：一项系统评价。
Basic Clin Neurosci. 2018 Mar-Apr;9(2):73-86. doi: 10.29252/nirp.bcn.9.2.73.
6
Chagas Disease Recommendations for Solid-Organ Transplant Recipients and Donors.恰加斯病：实体器官移植受者和供者的建议
Transplantation. 2018 Feb;102(2S Suppl 2):S1-S7. doi: 10.1097/TP.0000000000002019.
7
Central nervous system syndromes in solid organ transplant recipients.实体器官移植受者的中枢神经系统综合征。
Clin Infect Dis. 2014 Oct;59(7):1001-11. doi: 10.1093/cid/ciu428. Epub 2014 Jun 9.
8
Trypanosoma cruzi meningoencephalitis in a patient with acquired immunodeficiency syndrome.一名获得性免疫缺陷综合征患者的克氏锥虫性脑膜脑炎
Am J Trop Med Hyg. 2014 Jul;91(1):84-5. doi: 10.4269/ajtmh.14-0058. Epub 2014 Jun 2.
9
Heart transplantation for Chagas cardiomyopathy in the United States.美国的克山病心肌病心脏移植。
Am J Transplant. 2013 Dec;13(12):3262-8. doi: 10.1111/ajt.12507. Epub 2013 Oct 28.
10
Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas.非流行地区器官和造血组织移植项目中恰加斯病管理的建议。
Transplant Rev (Orlando). 2011 Jul;25(3):91-101. doi: 10.1016/j.trre.2010.12.002. Epub 2011 Apr 29.

通过脑脊液宏基因组下一代测序在心脏移植患者中诊断出查加斯脑膜脑炎。

Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid.

作者信息

Teitelbaum Jill, Madan Shivank, Patel Snehal, Coyle Christina, Chiu Charles Y, Thwe Phyu M, Uehara Mayuko, Jermyn Rita, Hemmige Vagish

机构信息

Albert Einstein College of Medicine, Bronx, New York.

Montefiore Medical Center, Bronx, New York.

出版信息

Am J Trop Med Hyg. 2025 May 6;113(1):32-36. doi: 10.4269/ajtmh.24-0553. Print 2025 Jul 2.

DOI:10.4269/ajtmh.24-0553
PMID:40328237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12225569/
Abstract

Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.

摘要

恰加斯脑膜脑炎可出现在器官移植后的免疫功能低下患者中。我们报告了首例通过脑脊液宏基因组下一代测序（mNGS）诊断出恰加斯脑膜脑炎的病例。该病例中恰加斯病的诊断突出了mNGS在识别罕见或意外病原体方面的作用。