Madelung Christopher F, Løkkegaard Annemette, Fuglsang Søren A, Marques Marta M, Boer Vincent O, Madsen Kristoffer H, Hejl Anne-Mette, Meder David, Siebner Hartwig R
Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Copenhagen, Denmark.
Department of Neurology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
NPJ Parkinsons Dis. 2025 May 6;11(1):113. doi: 10.1038/s41531-025-00972-7.
Parkinson's disease causes a progressive loss of dopaminergic neurons and iron accumulation in the substantia nigra pars compacta. Using ultra-high field magnetic resonance imaging (MRI) at 7 tesla in 43 Parkinson's patients and 24 healthy controls, we analyzed the voxel-wise pattern of structural disintegration of dopamine neurons with neuromelanin-sensitive MRI, along with assessing iron accumulation using R2* and quantitative susceptibility mapping (QSM). We also explored correlations between these measures and the severity of residual motor symptoms in the on-medication state and other clinical variables. Differences were most notable in the nigrosomes within the pars compacta, with patients showing reduced neuromelanin signals and increased QSM values. Severity and asymmetry of motor symptoms correlated with higher R2* and QSM values in nigrosome N1. Thus, ultra-high field MRI provides high-resolution maps of various aspects of the underlying neurodegenerative process which reflect individual motor impairment in Parkinson's disease.
帕金森病会导致多巴胺能神经元进行性丧失以及黑质致密部铁蓄积。我们对43例帕金森病患者和24名健康对照者进行了7特斯拉的超高场磁共振成像（MRI）检查，利用对神经黑素敏感的MRI分析多巴胺神经元结构解体的体素模式，并使用R2和定量磁化率图谱（QSM）评估铁蓄积情况。我们还探究了这些测量指标与服药状态下残余运动症状严重程度及其他临床变量之间的相关性。差异在致密部的黑质小体中最为显著，患者表现为神经黑素信号降低和QSM值升高。运动症状的严重程度和不对称性与黑质小体N1中较高的R2和QSM值相关。因此，超高场MRI提供了潜在神经退行性过程各个方面的高分辨率图谱，反映了帕金森病患者的个体运动障碍。
