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利用飞行显微镜在微重力环境下结合微流控技术进行显微镜检查。

Microscopy with microfluidics in microgravity using FlightScope.

作者信息

Wareing Thomas, Stokes Alexander, Crompton Katrina E, Murphy Koren, Dawson Jack, Ugurluoglu Yusuf Furkan, Richardson Connor, Li Hongquan, Prakash Manu, Wollman Adam J M

机构信息

School of Engineering, Newcastle University, Newcastle-Upon-Tyne, NE2 4HH, UK.

Newcastle University Biosciences Institute, Newcastle-Upon-Tyne, NE2 4HH, UK.

出版信息

NPJ Microgravity. 2025 May 6;11(1):13. doi: 10.1038/s41526-025-00470-3.

DOI:10.1038/s41526-025-00470-3
PMID:40328826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056092/
Abstract

With planned missions to the moon and Mars, it has never been more important to study the impact of microgravity on biological organisms. Parabolic flights are one of the most accessible microgravity research platforms but present challenges: short periods of microgravity and aircraft vibration. Live-imaging is necessary to readout any real-time phenotypes so we developed FlightScope, a new microscopy and microfluidics platform to study dynamic cellular processes in microgravity.

摘要

随着计划中的月球和火星任务，研究微重力对生物机体的影响变得前所未有的重要。抛物线飞行是最容易获得的微重力研究平台之一，但也存在挑战：微重力时间短且飞机振动。实时成像对于读取任何实时表型是必要的，因此我们开发了FlightScope，这是一个新的显微镜和微流控平台，用于研究微重力下的动态细胞过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/a7c866044529/41526_2025_470_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/03bd1b46818c/41526_2025_470_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/f2068d947c8c/41526_2025_470_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/7c929590d56f/41526_2025_470_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/f4260be819a9/41526_2025_470_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/a7c866044529/41526_2025_470_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/03bd1b46818c/41526_2025_470_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/f2068d947c8c/41526_2025_470_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/7c929590d56f/41526_2025_470_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/f4260be819a9/41526_2025_470_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c81/12056092/a7c866044529/41526_2025_470_Fig5_HTML.jpg

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