Kohanfekr Tahmineh, Gholamrezazadeh Camelia, Hosseini Hasan Ali
Chemistry Department, Payame Noor University, Tehran, 19395-4697, Iran.
Biometals. 2025 May 6. doi: 10.1007/s10534-025-00683-9.
Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.
以8-羟基喹啉配体及其衍生物为特征的钒配合物已成为一类具有潜在治疗应用前景的化合物，特别是作为抗菌和抗癌剂。这篇综述全面及时且富有见地地分析了含HQ配体或其衍生物的钒配合物的现状，无论其单独存在还是与有机共配体结合。本文综述了其合成策略以及抗菌和抗癌活性的潜在机制。本综述的一个重要重点是对这些配合物的抗菌和抗癌特性进行全面评估，为无机化学、药物化学和药物发现等跨学科领域的研究人员提供了宝贵的资源。通过汇编和综合关于钒-8-羟基喹啉（VO-8HQ）配合物的现有知识，本综述填补了文献中的一个关键空白。正在进行的研究，包括严格的临床前和临床评估，对于充分探索这类有前景的金属药物的治疗潜力至关重要。
