Park Jong-Beom, Lee Gun Woo
Department of Orthopedic Surgery, Uijeongbu St. Mary Hospital, The Catholic University of Korea College of Medicine, 271 Cheonbo-ro, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
Department of Orthopedic Surgery, Yeungnam University College of Medicine, Yeungnam University Medical Center, 170 Hyonchung-ro, Namgu, Daegu, 42415, Republic of Korea.
J Clin Orthop Trauma. 2025 Apr 11;66:103014. doi: 10.1016/j.jcot.2025.103014. eCollection 2025 Jul.
Degenerative cervical myelopathy (DCM) is a progressive degenerative disorder of the spinal cord that can lead to significant and irreversible neurological deficits if left untreated. Determining the most appropriate treatment strategy requires a thorough assessment of disease severity, patient-specific factors, and comparative benefits of surgical versus non-surgical interventions. Conservative treatment, including physical therapy, pharmacological treatment, and lifestyle modifications, might be considered for patients with mild symptoms and those deemed unsuitable for surgery. However, for cases with moderate to severe myelopathy or progressive neurological deterioration, surgical treatment remains the gold standard. Surgical options-including anterior cervical discectomy and fusion (ACDF), anterior cervical corpectomy and fusion (ACCF), laminoplasty, and laminectomy with or without fusion-should be selected based on the pattern of spinal cord compression, sagittal alignment, and patient comorbidities. ACDF and ACCF are preferred for focal anterior compression at limited levels, whereas laminoplasty is generally indicated for multilevel posterior compression in patients with preserved cervical lordosis. For cases with cervical kyphosis or significant instability, laminectomy with fusion is often required. In certain complex cases, a combined anterior-posterior approach may be necessary to achieve adequate decompression, restore spinal alignment, and enhance stability, particularly in patients with severe deformities or multilevel involvement. Recent advances in minimally invasive spine surgery and motion-preserving techniques, such as cervical disc arthroplasty (CDA), have broadened the spectrum of treatment options, offering potential benefits for reducing perioperative morbidity and preserving segmental motion. Additionally, acute spinal cord injury due to trauma in a spondylotic spine, particularly central cord syndrome (CCS), represents a critical consideration in treatment planning. The role of anterior versus posterior surgery, including the rationale for decision-making, has been expanded to highlight key factors such as sagittal vertical axis, T1 slope, and spinal alignment. Moreover, we discuss the role of laminectomy without fusion in DCM management, evaluating its indications and limitations. Decision-making must carefully weigh patient-reported outcomes, complication risks, and long-term functional prognosis. This review provides an expert synthesis of current evidence and guidelines for DCM treatment, integrating the latest surgical innovations and a patient-centered approach to optimize clinical outcomes.
退行性颈椎脊髓病(DCM)是一种脊髓的进行性退行性疾病,如果不治疗,可导致严重且不可逆的神经功能缺损。确定最合适的治疗策略需要全面评估疾病严重程度、患者特定因素以及手术与非手术干预的相对益处。对于症状较轻以及被认为不适合手术的患者,可考虑保守治疗,包括物理治疗、药物治疗和生活方式改变。然而,对于中度至重度脊髓病或进行性神经功能恶化的病例,手术治疗仍是金标准。手术选择包括颈椎前路椎间盘切除融合术(ACDF)、颈椎前路椎体次全切除融合术(ACCF)、椎板成形术以及有无融合的椎板切除术,应根据脊髓受压模式、矢状位对线和患者合并症来选择。ACDF和ACCF适用于有限节段的局灶性前路压迫,而椎板成形术通常适用于颈椎生理前凸保留的患者的多节段后路压迫。对于颈椎后凸或明显不稳定的病例,通常需要进行融合椎板切除术。在某些复杂病例中,可能需要采用前后联合入路以实现充分减压、恢复脊柱对线并增强稳定性,特别是对于严重畸形或多节段受累的患者。微创脊柱手术和保留运动技术(如颈椎间盘置换术(CDA))的最新进展拓宽了治疗选择范围,为降低围手术期发病率和保留节段运动提供了潜在益处。此外,颈椎病性脊柱外伤导致的急性脊髓损伤,尤其是中央脊髓综合征(CCS),是治疗计划中的关键考虑因素。前路与后路手术的作用,包括决策依据,已得到扩展,以突出矢状垂直轴、T1斜率和脊柱对线等关键因素。此外,我们讨论了非融合椎板切除术在DCM管理中的作用,评估其适应证和局限性。决策必须仔细权衡患者报告的结果、并发症风险和长期功能预后。本综述提供了DCM治疗的当前证据和指南的专家综合意见,整合了最新的手术创新和以患者为中心的方法,以优化临床结果。