男性和女性中与特发性不孕相关的久坐行为、身体活动不足与身体成分。
Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women.
机构信息
Université Paris 13, Sorbonne Paris Cité, Laboratoire Educations et Pratiques de Santé (LEPS) EA 3412, UFR SMBH, Bobigny, France.
AP-HP, Hôpital Tenon, service de biologie de la reproduction CECOS, Paris, France.
出版信息
PLoS One. 2019 Apr 24;14(4):e0210770. doi: 10.1371/journal.pone.0210770. eCollection 2019.
BACKGROUND
Physical activity (PA) and sedentary behavior have inconsistent effects on fertility. High body mass index is associated with infertility but to our knowledge, very few studies have explored body composition in association to fertility.
OBJECTIVE
To assess the association between physical inactivity, sedentary behavior, body composition and idiopathic infertility in French men and women.
DESIGN
We conducted a case-control multicentric observational study. 159 infertile (79 men and 80 women) and 143 fertile (72 men and 71 women) were recorded in four fertility centers.
MAIN OUTCOME MEASURES
Participants completed self-administered questionnaires on sociodemographic and lifestyle characteristics, dietary intake, physical activity and sedentary behavior. Anthropometrics were measured, and bioelectrical impedance analysis was used to estimate body composition. Multivariable logistic regression was used to analyze the association of fertility with PA level and sedentary behavior.
RESULTS
In men, being physically inactive (Odd ratio [OR] 2.20; 95% confidence interval [CI], 1.06, 4.58) and having fat mass greater than the reference values for their age (OR 2.83; 95%CI, 1.31, 6.10) were positively associated with infertility. Sedentary behavior and fat-free mass were not related to infertility in men. In women, sedentary behavior (OR 3.61; 95%CI, 1.58, 8.24), high body fat (OR 3.16; 95%CI, 1.36, 7.37) and low fat-free mass (OR 2.65; 95%CI, 1.10, 6.37) were associated with infertility. PA level was not associated with fertility in women.
CONCLUSIONS
This study suggests that sedentary behavior and physical inactivity would represent two independent risk factors associated with infertility. The various elements that make up physical activity (frequency, intensity, time, and type of exercise) and the interrupting time spent sitting should be considered. Body composition variation should be explored further in relation to the biological pathways involved in idiopathic infertility. Moreover, the improvement of lifestyle factors should be considered in infertility treatment.
背景
体力活动（PA）和久坐行为对生育能力的影响不一致。高体重指数与不孕有关，但据我们所知，很少有研究探讨身体成分与生育能力的关系。
目的
评估法国男性和女性中体力活动不足、久坐行为、身体成分与特发性不孕之间的关系。
设计
我们进行了一项病例对照多中心观察性研究。在四个生育中心记录了 159 名不孕（79 名男性和 80 名女性）和 143 名生育（72 名男性和 71 名女性）的参与者。
主要结果测量
参与者完成了关于社会人口统计学和生活方式特征、饮食摄入、体力活动和久坐行为的自我管理问卷。测量了人体测量学数据，并使用生物电阻抗分析来估计身体成分。多变量逻辑回归用于分析生育能力与 PA 水平和久坐行为的关系。
结果
在男性中，体力活动不足（比值比 [OR] 2.20；95%置信区间 [CI]，1.06，4.58）和体脂肪量大于其年龄的参考值（OR 2.83；95%CI，1.31，6.10）与不孕呈正相关。久坐行为和去脂体重与男性不孕无关。在女性中，久坐行为（OR 3.61；95%CI，1.58，8.24）、高体脂肪（OR 3.16；95%CI，1.36，7.37）和低去脂体重（OR 2.65；95%CI，1.10，6.37）与不孕有关。女性的 PA 水平与生育能力无关。
结论
本研究表明，久坐行为和体力活动不足是与不孕相关的两个独立危险因素。应考虑构成体力活动的各种因素（频率、强度、时间和运动类型）以及久坐中断时间。应进一步探讨身体成分变化与特发性不孕相关的生物学途径的关系。此外，应考虑在不孕治疗中改善生活方式因素。
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