Wang Pan, Su Zheng, Sun Chen, Yao Wen-Hui, Zeng Yue-Ping
School of Medicine, Sun Yat-Sen University, Shenzhen, People's Republic of China.
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, People's Republic of China.
J Asthma Allergy. 2025 May 2;18:675-682. doi: 10.2147/JAA.S522343. eCollection 2025.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense pruritus. The principal pathological features include abnormalities in the structure and function of the epidermis, as well as skin inflammation marked by the overexpression of T helper 2 cell (Th2) cytokines. Throughout the progression of AD, various immune cells contribute to its pathogenesis. Basophils, the least abundant granulocytes in the human peripheral circulation, have historically been overlooked. However, the advent of novel research tools has facilitated a renewed focus on the role of basophils in diverse physiological and pathological conditions, including AD. Accordingly, this review will primarily summarize the association between AD and basophils, the alterations observed in basophils among AD patients, and the implications of these changes for AD patients.
特应性皮炎（AD）是一种以剧烈瘙痒为特征的慢性炎症性皮肤病。主要病理特征包括表皮结构和功能异常，以及以辅助性T细胞2（Th2）细胞因子过度表达为特征的皮肤炎症。在AD的整个病程中，多种免疫细胞参与其发病机制。嗜碱性粒细胞是人类外周循环中数量最少的粒细胞，在历史上一直被忽视。然而，新型研究工具的出现促使人们重新关注嗜碱性粒细胞在包括AD在内的各种生理和病理状况中的作用。因此，本综述将主要总结AD与嗜碱性粒细胞之间的关联、AD患者嗜碱性粒细胞中观察到的变化，以及这些变化对AD患者的影响。
