D'Andrea Lucas, Mosqueira Raphael, Filho Alcenor C Miranda, Marchetti Renato L
Department of Neuropsychiatry, Institute of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Epilepsy Behav Rep. 2025 Apr 12;30:100768. doi: 10.1016/j.ebr.2025.100768. eCollection 2025 Jun.
Wilson's disease (WD) is a rare disorder characterized by abnormal copper metabolism, leading to its accumulation in various tissues, particularly the brain and the liver. Psychiatric and neurological symptoms are common manifestations of WD. We present a case of a 22-year-old woman diagnosed with WD who exhibited neurological symptoms and experienced functional seizures (FS) that were misdiagnosed as epilepsy secondary to WD for almost two years. The patient's history of childhood trauma and interpersonal difficulties underscored the complex interplay between organic and psychogenic factors contributing to FS development. This case highlights the diagnostic challenges associated with the neuropsychiatric manifestations of Wilson's disease, as well as the complexities in differentiating functional seizures from epilepsy. It emphasizes the importance of comprehensive assessment and multidisciplinary care in optimizing patient outcomes.
威尔逊病（WD）是一种罕见的疾病，其特征是铜代谢异常，导致铜在各种组织中蓄积，尤其是大脑和肝脏。精神和神经症状是WD的常见表现。我们报告一例22岁女性被诊断为WD，她出现了神经症状，并经历了功能性癫痫发作（FS），被误诊为继发于WD的癫痫近两年。患者童年创伤和人际困难的病史突显了导致FS发生的器质性和心理因素之间复杂的相互作用。该病例突出了与威尔逊病神经精神表现相关的诊断挑战，以及区分功能性癫痫发作和癫痫的复杂性。它强调了全面评估和多学科护理在优化患者预后方面的重要性。
