Litwin Tomasz, Dusek Petr, Szafrański Tomasz, Dzieżyc Karolina, Członkowska Anna, Rybakowski Janusz K
Second Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Polandc.
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Ther Adv Psychopharmacol. 2018 Jul;8(7):199-211. doi: 10.1177/2045125318759461. Epub 2018 Mar 6.
Wilson's disease (WD) is an inherited metabolic disorder related to disturbances of copper metabolism, and predominantly presents with liver and neuropsychiatric symptoms. In most cases it can be successfully treated with anti-copper agents, and both liver function and neuropsychiatric symptoms typically improve. Treatment guidelines for WD include recommendations for anti-copper treatment as well as for the treatment of liver failure symptoms. Recently, recommendations for treatment of the neurological symptoms of WD have also been proposed. Although most WD patients present with psychiatric symptoms at some stage of the disease, currently there are no guidelines for the treatment of the psychiatric manifestations. Treatment of the psychiatric symptoms of WD is often guided by general psychiatric experience, which typically glosses over the specificity of WD, and can result in severe neurological and/or hepatic complications. Here we review and discuss the possible treatments available for the mood disturbances, psychosis, behavioral and cognitive disorders that can occur in WD, as well as their efficacy.
威尔逊病（WD）是一种与铜代谢紊乱相关的遗传性代谢疾病，主要表现为肝脏和神经精神症状。在大多数情况下，使用抗铜药物可以成功治疗，肝功能和神经精神症状通常会改善。WD的治疗指南包括抗铜治疗以及肝衰竭症状治疗的建议。最近，也提出了WD神经症状治疗的建议。尽管大多数WD患者在疾病的某个阶段会出现精神症状，但目前尚无针对精神症状表现的治疗指南。WD精神症状的治疗通常以一般精神科经验为指导，这通常会忽略WD的特异性，并可能导致严重的神经和/或肝脏并发症。在此，我们回顾并讨论可用于治疗WD中可能出现的情绪障碍、精神病、行为和认知障碍的可用治疗方法及其疗效。
