Guerrero Gloria G, Madrid-Marina Vicente, Martínez-Romero Aurora, Torres-Poveda Kirvis, Favela-Hernández Juan Manuel
Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas 98600, Zac., Mexico.
Centro de Investigación en Enfermedades infecciosas (CISEI), Instituto Nacional de Salud Pública (INSP), Cuernavaca 62100, Mor., Mexico.
Vaccines (Basel). 2025 Apr 16;13(4):418. doi: 10.3390/vaccines13040418.
Vaccine formulations are a successful strategy against pathogen transmission because vaccine candidates induce effective and long-lasting memory immune responses (B and CD4+ T cells) at systemic and mucosal sites. Extracellular vesicles of lipoproteins, bioactive compounds from plants and invertebrates (sponges) encapsulated in liposomes, and glycoproteins can target these sites. The vaccine candidates developed can mimic microbial pathogens in a way that successfully links the innate and adaptive immune responses. In addition, vaccines plus adjuvants promote and maintain an inflammatory response. In this review, we aimed to identify the host-pathogen interface as a rich source of candidate targets for vaccine-induced protective and long-lasting memory immune responses.
疫苗制剂是对抗病原体传播的成功策略，因为候选疫苗可在全身和黏膜部位诱导有效且持久的记忆免疫反应（B细胞和CD4+T细胞）。脂蛋白细胞外囊泡、包裹在脂质体中的植物和无脊椎动物（海绵）的生物活性化合物以及糖蛋白可靶向这些部位。所开发的候选疫苗能够以成功连接先天免疫和适应性免疫反应的方式模拟微生物病原体。此外，疫苗加佐剂可促进并维持炎症反应。在本综述中，我们旨在确定宿主-病原体界面是疫苗诱导的保护性和持久记忆免疫反应候选靶点的丰富来源。
