Petkova Margarita Koleva, Grozeva Neli Hristova, Tzanova Milena Tankova, Todorova Mima Hristova
Department of Biological Sciences, Faculty of Agriculture, Trakia University, 6000 Stara Zagora, Bulgaria.
Department of Plant Breeding, Faculty of Agriculture, Trakia University, 6000 Stara Zagora, Bulgaria.
Molecules. 2025 Apr 21;30(8):1856. doi: 10.3390/molecules30081856.
(Yellow Bedstraw) is a rhizomatous perennial herb belonging to the Rubiaceae family. It is native to Eurasia and Africa but has also been introduced to southern Canada and the northern U.S. Widely used in traditional medicine, has been recognized for its diuretic, anti-inflammatory, antimicrobial, analgesic, and anticancer properties. Phytochemical studies have shown that the plant is rich in significant bioactive compounds, such as flavonoids, phenolic acids, iridoids, anthraquinones, phytosterols, coumarins, and tannins. Research suggests that exhibits strong antioxidant activity, protecting cells from oxidative stress and inflammation. Its antimicrobial potential has been demonstrated against various bacterial and fungal pathogens, supporting its traditional use in wound healing and infection treatment. Moreover, modern studies indicate its cytotoxic effects on cancer cells, suggesting potential applications in oncology. Additionally, its hepatoprotective and neuroprotective properties highlight its promise for treating metabolic and neurodegenerative disorders. Despite its well-known therapeutic potential, further studies are required to fully clarify its mechanisms of action and ensure its safety for medicinal use. Given the variety of bioactive compounds found in and their pharmacological benefits, this review emphasizes the importance of this species as a valuable medicinal plant, encouraging further scientific research for its application in pharmacology.
（黄猪殃殃）是一种属于茜草科的多年生草本植物，具根状茎。它原产于欧亚大陆和非洲，但也已被引入加拿大南部和美国北部。它在传统医学中被广泛使用，因其利尿、抗炎、抗菌、止痛和抗癌特性而得到认可。植物化学研究表明，该植物富含重要的生物活性化合物，如黄酮类化合物、酚酸、环烯醚萜、蒽醌、植物甾醇、香豆素和单宁。研究表明，它具有很强的抗氧化活性，可保护细胞免受氧化应激和炎症的影响。它对各种细菌和真菌病原体的抗菌潜力已得到证实，这支持了它在伤口愈合和感染治疗中的传统用途。此外，现代研究表明它对癌细胞具有细胞毒性作用，表明其在肿瘤学中的潜在应用。此外，它的肝脏保护和神经保护特性突出了其在治疗代谢和神经退行性疾病方面的前景。尽管其治疗潜力众所周知，但仍需要进一步研究以充分阐明其作用机制并确保其药用安全性。鉴于在黄猪殃殃中发现的多种生物活性化合物及其药理益处，本综述强调了该物种作为一种有价值的药用植物的重要性，鼓励对其在药理学中的应用进行进一步的科学研究。
