Razzivina Valerija, Vasiljeva Anna, Kronberga Arta, Skudrins Gundars, Nakurte Ilva, Zogota Marta, Mezaka Ieva, Pugovics Osvalds, Grinberga Solveiga, Dambrova Maija, Sile Inga
Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006 Riga, Latvia.
Department of Pharmaceutical Chemistry, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, Latvia.
Antioxidants (Basel). 2024 Nov 25;13(12):1447. doi: 10.3390/antiox13121447.
, commonly known as sweet woodruff, is a perennial herbaceous plant that contains coumarin and is recognized for its medicinal properties. In this study, the influence of sunlight exposure on the phytochemical composition and anti-inflammatory potential of extracts is assessed. The extracts from cultivated and wild-grown plants were analyzed via chromatographic and mass spectrometric methods. In addition, the total phenolic content, antioxidant activity, and effects on macrophage polarization were assessed. The results revealed that while coumarin levels remain stable regardless of environmental conditions, phenolic content and antioxidant activity increase significantly under sun-grown conditions, with chlorogenic acid and rutin identified as major contributing compounds. Additionally, the extracts exhibited anti-inflammatory activity, effectively reducing the M1 macrophage population involved in inflammatory responses. These findings suggest that controlled sunlight exposure can enhance the bioactive profile of . This research highlights the critical role of environmental management in optimizing the medicinal properties of , providing a foundation for its future use in natural therapeutic applications.
，通常被称为香车叶草，是一种多年生草本植物，含有香豆素，并因其药用特性而闻名。在本研究中，评估了阳光照射对提取物的植物化学成分和抗炎潜力的影响。通过色谱和质谱方法分析了栽培植物和野生植物的提取物。此外，还评估了总酚含量、抗氧化活性以及对巨噬细胞极化的影响。结果表明，无论环境条件如何，香豆素水平保持稳定，而在阳光照射条件下，酚类含量和抗氧化活性显著增加，其中绿原酸和芦丁被确定为主要贡献化合物。此外，提取物表现出抗炎活性，有效减少了参与炎症反应的M1巨噬细胞群体。这些发现表明，控制阳光照射可以增强提取物的生物活性特征。本研究突出了环境管理在优化提取物药用特性方面的关键作用，为其未来在自然治疗应用中的使用提供了基础。
