Zahra Mehak, Abrahamse Heidi, George Blassan P
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 1711, Doornfontein 2028, South Africa.
Antioxidants (Basel). 2024 Jul 29;13(8):922. doi: 10.3390/antiox13080922.
This study emphasizes the critical role of antioxidants in protecting human health by counteracting the detrimental effects of oxidative stress induced by free radicals. Antioxidants-found in various forms such as vitamins, minerals, and the phytochemicals abundant in fruits and vegetables-neutralize free radicals by stabilizing them through electron donation. Specifically, flavonoid compounds are highlighted as robust defenders, addressing oxidative stress and inflammation to avert chronic illnesses like cancer, cardiovascular diseases, and neurodegenerative diseases. This research explores the bioactive potential of flavonoids, shedding light on their role not only in safeguarding health, but also in managing conditions such as diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases. This review highlights the novel integration of South African-origin flavonoids with nanotechnology, presenting a cutting-edge strategy to improve drug delivery and therapeutic outcomes. This interdisciplinary approach, blending traditional wisdom with contemporary techniques, propels the exploration of flavonoid-mediated nanoparticles toward groundbreaking pharmaceutical applications, promising revolutionary advancements in healthcare. This collaborative synergy between traditional knowledge and modern science not only contributes to human health, but also underscores a significant step toward sustainable and impactful biomedical innovations, aligning with principles of environmental conservation.
本研究强调了抗氧化剂在保护人类健康方面的关键作用，即通过对抗自由基诱导的氧化应激的有害影响来实现。抗氧化剂以多种形式存在，如维生素、矿物质以及水果和蔬菜中丰富的植物化学物质，它们通过电子供体使自由基稳定，从而中和自由基。具体而言，类黄酮化合物被视为强大的防御者，可应对氧化应激和炎症，以预防癌症、心血管疾病和神经退行性疾病等慢性疾病。本研究探索了类黄酮的生物活性潜力，不仅揭示了它们在维护健康方面的作用，还阐明了它们在管理糖尿病、癌症、心血管疾病和神经退行性疾病等病症方面的作用。这篇综述强调了南非原产类黄酮与纳米技术的新型整合，提出了一种前沿策略，以改善药物递送和治疗效果。这种将传统智慧与当代技术相结合的跨学科方法，推动了对类黄酮介导的纳米颗粒在开创性药物应用方面的探索，有望在医疗保健领域取得革命性进展。传统知识与现代科学之间的这种协同合作不仅有助于人类健康，还凸显了朝着可持续且有影响力的生物医学创新迈出的重要一步，符合环境保护原则。
