Zhu Hengjia, Deng Qiyu, Li Junzhi, Yang Ling, Li Hegeng, Zhao Zhipeng, Wang Zuochen, Pang Chunlin, Zhang Yiyuan, Lui Vincent Chi-Hang, Li Wei, Yin Xiaobo, Wang Liqiu
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR 999077, P.R. China.
Department of Surgery, The University of Hong Kong, Hong Kong SAR 999077, P.R. China.
Sci Adv. 2025 May 9;11(19):eadv6314. doi: 10.1126/sciadv.adv6314. Epub 2025 May 7.
Precision processing of various liquids while maintaining their purity holds immense potential for many applications. However, liquids tend to leave residues that contaminate handling tools and compromise volumetric precision, necessitating contactless strategies to prevent liquid loss. Biological and chemical samples carried by fluids can be sensitive to physical stimuli, demanding mild but effective means to preserve integrity. Here, we report a sound-controlled fluidic processor for complete and well-controlled microfluidic functions, including moving, merging, mixing, and cleaving, in contactless and harmless manners. The processor generates an acoustophoretic force field that serves as a versatile toolbox for manipulating droplets with surface tension from 17.9 to 72 millinewtons per meter and volume from 1 nanoliter to 3 milliliters, offering a wealth of operations crucial to fundamental biomedical and chemical practices.
在保持各种液体纯度的同时对其进行精确处理，在许多应用中具有巨大潜力。然而，液体往往会留下残留物，污染处理工具并影响体积精度，因此需要采用非接触式策略来防止液体损失。流体携带的生物和化学样品可能对物理刺激敏感，需要温和而有效的方法来保持其完整性。在此，我们报告了一种声控流体处理器，它能够以非接触和无害的方式实现完整且可控的微流体功能，包括移动、合并、混合和裂解。该处理器产生一个声泳力场，可作为一个多功能工具箱，用于操控表面张力从每米17.9毫牛顿到72毫牛顿、体积从1纳升到3毫升的液滴，提供了一系列对基础生物医学和化学实践至关重要的操作。
