Jiang Shaojun, Li Bo, Zhao Jun, Wu Dong, Zhang Yiyuan, Zhao Zhipeng, Zhang Yiyuan, Yu Hao, Shao Kexiang, Zhang Cong, Li Rui, Chen Chao, Shen Zuojun, Hu Jie, Dong Bin, Zhu Ling, Li Jiawen, Wang Liqiu, Chu Jiaru, Hu Yanlei
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.
Nat Commun. 2023 Sep 6;14(1):5455. doi: 10.1038/s41467-023-41092-1.
The versatile manipulation of cross-scale droplets is essential in many fields. Magnetic excitation is widely used for droplet manipulation due to its distinguishing merits. However, facile magnetic actuation strategies are still lacked to realize versatile multiscale droplet manipulation. Here, a type of magnetically actuated Janus origami robot is readily fabricated for versatile cross-scale droplet manipulation including three-dimensional transport, merging, splitting, dispensing and release of daughter droplets, stirring and remote heating. The robot allows untethered droplet manipulation from ~3.2 nL to ~51.14 μL. It enables splitting of droplet, precise dispensing (minimum of ~3.2 nL) and release (minimum of ~30.2 nL) of daughter droplets. The combination of magnetically controlled rotation and photothermal properties further endows the robot with the ability to stir and heat droplets remotely. Finally, the application of the robot in polymerase chain reaction (PCR) is explored. The extraction and purification of nucleic acids can be successfully achieved.
跨尺度液滴的多功能操控在许多领域都至关重要。磁激发因其独特优点而被广泛用于液滴操控。然而，仍缺乏简便的磁驱动策略来实现多功能多尺度液滴操控。在此，一种磁驱动的双面折纸机器人被轻松制造出来，用于包括三维传输、合并、分裂、分配和释放子液滴、搅拌及远程加热在内的多功能跨尺度液滴操控。该机器人可实现约3.2纳升至约51.14微升的无系绳液滴操控。它能够实现液滴分裂、精确分配（最小约3.2纳升）和子液滴释放（最小约30.2纳升）。磁控旋转和光热特性的结合进一步赋予机器人远程搅拌和加热液滴的能力。最后，探索了该机器人在聚合酶链反应（PCR）中的应用。核酸的提取和纯化得以成功实现。
