Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA; email:
Department of Mechanical Engineering, Aydın Adnan Menderes University, Aydın 09010, Turkey; email:
Annu Rev Anal Chem (Palo Alto Calif). 2020 Jun 12;13(1):17-43. doi: 10.1146/annurev-anchem-090919-102205.
Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we summarize the physical principles underlying acoustic microfluidics and review their applications, with particular emphasis on the manipulation of macromolecules, cells, particles, model organisms, and fluidic flows. We also present future goals of this technology in analytical chemistry and biomedical research, as well as challenges and opportunities.
声微流控器件是一种强大的工具，利用声波来操控分析化学和生物医学领域中的微纳米级物体或流体。其简单的器件设计、生物兼容性和非接触式操作以及无标记的特性使得声微流控器件成为基础研究、诊断和治疗的理想平台。在此，我们总结了声微流控的物理原理，并综述了其应用，特别强调了对生物大分子、细胞、颗粒、模式生物和流体流动的操控。我们还展示了该技术在分析化学和生物医学研究中的未来目标，以及挑战和机遇。
