Liu Jie, Tao Zhang, Pu Wenfeng, Zhang Yan, Du Zonghan, Chen Long, Hu Dan, Chen Yanan, Li Guobin, Zhang Lisha, Yu Yiwen, Wei Fuxia
Department of Gastroenterology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
PLoS One. 2025 May 7;20(5):e0323226. doi: 10.1371/journal.pone.0323226. eCollection 2025.
The current treatment options for phytobezoars include endoscopic therapy, chemical lysis, and surgical treatment. These methods are often less efficient or are associated with more adverse events in large-diameter phytobezoars. This study aimed to evaluate the feasibility, effectiveness, and safety of the cap-assisted 5-cm diameter cold snare technique for the treatment of huge phytobezoars.
This retrospective study enrolled 24 patients with huge phytobezoars treated with the cap-assisted 5-cm diameter cold snare technique in the Department of Gastroenterology, Nanchong Central Hospital, between December 25, 2022, and October 1, 2023. Patients' clinical characteristics and bezoar features were evaluated, the procedure was recorded, and patients were reviewed and followed with gastroscopy 1 day and 1 month after the procedure.
Twenty-four patients with huge phytobezoars were treated with the cap-assisted 5-cm diameter cold snare technique during the study period. The median phytobezoar size, break-up time, and extraction time were 5 × 3 cm (range 4-10, 3-5), 10.08 minutes (range 3.31-31.48), and 9.63 minutes (range 6.5-35.71), respectively. All patients achieved satisfactory treatment results, with no residual phytobezoars or gastrointestinal injuries on gastroscopy review 1 day after the procedure, and no postoperative adverse events were found on gastroscopy follow-up 1 month after the procedure.
The results of this study indicated that the cap-assisted 5-cm diameter cold snare technique is safe, feasible, and effective for treating huge gastric bezoars, offering a new treatment method for this disease. Given the limitations inherent in the retrospective nature and relatively small sample size of this study, a prospective, multicenter, large-sample clinical trial is warranted to evaluate the efficacy and generalizability of this technique comprehensively.
目前植物性胃石的治疗选择包括内镜治疗、化学溶解和手术治疗。对于大直径植物性胃石,这些方法通常效率较低或伴有更多不良事件。本研究旨在评估帽辅助直径5厘米冷圈套技术治疗巨大植物性胃石的可行性、有效性和安全性。
本回顾性研究纳入了2022年12月25日至2023年10月1日期间在南充市中心医院消化内科接受帽辅助直径5厘米冷圈套技术治疗的24例巨大植物性胃石患者。评估患者的临床特征和胃石特征,记录手术过程,并在术后1天和1个月进行胃镜复查和随访。
在研究期间,24例巨大植物性胃石患者接受了帽辅助直径5厘米冷圈套技术治疗。胃石的中位大小、破碎时间和取出时间分别为5×3厘米(范围4 - 10,3 - 5)、10.08分钟(范围3.31 - 31.48)和9.63分钟(范围6.5 - 35.71)。所有患者均取得满意的治疗效果,术后1天胃镜复查无残留植物性胃石或胃肠道损伤,术后1个月胃镜随访未发现术后不良事件。
本研究结果表明,帽辅助直径5厘米冷圈套技术治疗巨大胃石安全、可行且有效,为该病提供了一种新的治疗方法。鉴于本研究回顾性性质和相对较小样本量的固有局限性,有必要进行一项前瞻性、多中心、大样本的临床试验,以全面评估该技术的疗效和可推广性。