Li Bo, Li Bingzhi, Qiao Xianghe, Meng Wanrong, Xie Yuhang, Gong Jiajing, Fan Yi, Zhao Zhihe, Li Longjiang
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Trends Mol Med. 2025 May 6. doi: 10.1016/j.molmed.2025.04.002.
Despite the primary impression of mitochondria as energy factories, these organelles are increasingly recognized for their multifaceted roles beyond energy production. Intriguingly, mitochondria can transfer between cells, influencing physiological and pathological processes through intercellular trafficking termed 'mitochondrial transfer.' This phenomenon is important in maintaining metabolic homeostasis, enhancing tissue regeneration, exacerbating cancer progression, and facilitating immune modulation, depending on the cell type and microenvironment. Recently, mitochondrial transfer has emerged as a promising therapeutic target for tissue repair and antitumor therapy. Here, we summarize and critically review recent advances in this field. We aim to provide an updated overview of the mechanisms and potential therapeutic avenues associated with mitochondrial transfer in various diseases from the perspective of different donor cells.
尽管线粒体最初被认为是能量工厂，但这些细胞器因其在能量产生之外的多方面作用而越来越受到认可。有趣的是，线粒体可以在细胞间转移，通过称为“线粒体转移”的细胞间运输影响生理和病理过程。根据细胞类型和微环境，这种现象在维持代谢稳态、促进组织再生、加剧癌症进展和促进免疫调节方面都很重要。最近，线粒体转移已成为组织修复和抗肿瘤治疗的一个有前景的治疗靶点。在此，我们总结并批判性地回顾了该领域的最新进展。我们旨在从不同供体细胞的角度，提供与线粒体转移在各种疾病中相关的机制和潜在治疗途径的最新概述。
