Thakur Neeraj, Shukla S K, Kumar Mahesh, Chethan G E, Singh Alok, Singh Anand Kumar, Mandal Kruti Debnath, Saminathan M, Choudhary Priyanka, De U K, Sarma Kalyan
Department of Veterinary Medicine, College of Veterinary and Animal Sciences, GBPUA&T, Pantnagar, Uttarakhand, India.
Department of Veterinary Medicine, College of Veterinary Sciences and Animal Husbandry, CAU, Selesih, Aizawl, Mizoram, India.
Ann Med Surg (Lond). 2025 Apr 2;87(5):2674-2688. doi: 10.1097/MS9.0000000000003230. eCollection 2025 May.
Antibacterial, antioxidant, and antilipidemic properties of are well known from previous studies. This study was designed to study the phytochemical constituents, antioxidant efficacy, nephroprotective activity, and immunomodulatory potential of hydroethanolic extract in gentamicin-induced acute kidney injury (AKI) rat model.
extract was given for 8 days to gentamicin-induced toxicity (100 mg/kg) in rats. Nephroprotective and immunomodulatory efficacy of extract was evaluated based on urine and serum biochemistry, blood and tissue oxidative stress indices, cytokine levels, kidney injury biomarkers, and histopathology.
Gentamicin toxicity resulted in a reduction in catalase, glutathione reductase, superoxide dismutase, and interleukin-10 levels in blood and tissue homogenates, while an increase in serum creatinine, blood urea nitrogen, lipid peroxide, tumor necrosis factor-alpha, cystatin C, kidney injury molecule-1, and gamma-glutamyl transpeptidase levels. Treatment with ameliorated oxidative stress, cytokine imbalance, and kidney injury; however, the results were almost similar to standard drug. Furthermore, histopathological analysis of kidney, liver, and heart tissues confirmed the organoprotective efficacy of extract.
The present findings demonstrate the curative efficacy of in gentamicin-induced AKI, probably mediated through phenolic and flavonoid phytoconstituents, antioxidant properties, and down-regulation of inflammatory cytokines. Therefore, future studies may be established to evaluate its efficacy and safety for clinical trials.
先前的研究已充分证实[提取物名称]具有抗菌、抗氧化和抗血脂特性。本研究旨在探讨[提取物名称]水乙醇提取物在庆大霉素诱导的急性肾损伤（AKI）大鼠模型中的植物化学成分、抗氧化功效、肾保护活性及免疫调节潜力。
将[提取物名称]给予庆大霉素诱导毒性（100mg/kg）的大鼠，持续8天。基于尿液和血清生化指标、血液和组织氧化应激指数、细胞因子水平、肾损伤生物标志物及组织病理学，评估[提取物名称]的肾保护和免疫调节功效。
庆大霉素毒性导致血液和组织匀浆中过氧化氢酶、谷胱甘肽还原酶、超氧化物歧化酶和白细胞介素-10水平降低，而血清肌酐、血尿素氮、脂质过氧化物、肿瘤坏死因子-α、胱抑素C、肾损伤分子-1和γ-谷氨酰转肽酶水平升高。[提取物名称]治疗可改善氧化应激、细胞因子失衡及肾损伤；然而，结果与标准药物几乎相似。此外，对肾脏、肝脏和心脏组织的组织病理学分析证实了[提取物名称]的器官保护功效。
本研究结果表明[提取物名称]对庆大霉素诱导的急性肾损伤具有治疗效果，可能是通过酚类和黄酮类植物成分、抗氧化特性以及炎症细胞因子的下调介导的。因此，未来可能需要开展研究以评估其在临床试验中的疗效和安全性。
