Kiasati Shiva, Rostami Mitra, Akram Zaid Mustafa, Hooshiar Mohammad Hosseini, Nasiri Kamyar, Hussein Wael Sheet, Momeni Haleh Salati, Farhadi Bahar
School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Ann Med Surg (Lond). 2025 Mar 28;87(5):2896-2903. doi: 10.1097/MS9.0000000000003194. eCollection 2025 May.
Micro-RNAs (miRNAs) have been found to play crucial roles in various biological processes and have been implicated in the development and progression of many diseases, including cancer. In recent years, several studies have suggested that miRNA may have a potential role in the relationship between oral burns and various. This systematic review aims to summarize the current evidence on the roles of miRNA in the relationship between oral burns and oral squamous cell carcinoma (OSCC).
The present systematic review was performed using PubMed, Google Scholar, Science Direct, ProQuest, Ovid, and Embase from April 2024 to May 2024 following the "Preferred Reporting Items for Systematic Reviews" guidelines. The keywords, including "oral burn OR burning tongue OR burning mouth" AND "Oral squamous cell carcinoma" AND "miRNA."
The study reviewed 9 publications, examining miRNA interactions common to oral burns and cancers. Among them, 5 studies focused on various burn types, while 4 addressed oral malignancies. Synthesizing these findings identified 5 shared miRNAs between burns and oral cancers. Regarding burn types, thermal burns were most mentioned, followed by carbon dioxide laser and chemical burns. For cancer, oral squamous cell carcinoma was predominant, with one study on tongue squamous cell carcinoma. Noteworthy miRNAs include hsa-miR-205, hsa-miR-18a, hsa-mir-23b, hsa-mir-203, and hsa-mir-150, each exhibiting distinct roles and expression patterns in burns and carcinogenesis.
Overall, the findings of this systematic review highlight the potential importance of miRNA in the relationship between oral burns and OSCC.
微小RNA（miRNA）已被发现参与多种生物学过程，并与包括癌症在内的许多疾病的发生和发展有关。近年来，多项研究表明，miRNA在口腔烧伤与多种疾病的关系中可能发挥潜在作用。本系统评价旨在总结目前关于miRNA在口腔烧伤与口腔鳞状细胞癌（OSCC）关系中作用的证据。
本系统评价按照“系统评价优先报告项目”指南，于2024年4月至2024年5月使用PubMed、谷歌学术、科学Direct、ProQuest、Ovid和Embase进行。关键词包括“口腔烧伤或灼口或灼口综合征”以及“口腔鳞状细胞癌”和“miRNA”。
该研究回顾了9篇出版物，研究了口腔烧伤和癌症共有的miRNA相互作用。其中，5项研究关注各种烧伤类型，4项涉及口腔恶性肿瘤。综合这些发现，确定了烧伤和口腔癌之间5种共同的miRNA。关于烧伤类型，热烧伤被提及最多，其次是二氧化碳激光烧伤和化学烧伤。对于癌症，口腔鳞状细胞癌占主导，有一项关于舌鳞状细胞癌的研究。值得注意的miRNA包括hsa-miR-205、hsa-miR-18a、hsa-mir-23b、hsa-mir-203和hsa-mir-150，它们在烧伤和致癌过程中各自表现出不同的作用和表达模式。
总体而言，本系统评价的结果突出了miRNA在口腔烧伤与OSCC关系中的潜在重要性。
